KPV

Synonyms: Lys-Pro-Val, KPV tripeptide, H-Lys-Pro-Val-OH

KPV is a synthetic tripeptide composed of lysine, proline, and valine. It corresponds to the C-terminal fragment of alpha-melanocyte-stimulating hormone (α-MSH), specifically residues 11-13. This small peptide has garnered significant attention in the cosmeceutical and pharmaceutical research sectors for its anti-inflammatory and immunomodulatory properties, offering a targeted approach to managing skin conditions and inflammatory pathways without the pigmentary effects associated with the full-length hormone.

Unlike many peptides that require complex conjugation for stability, KPV retains activity as a standalone molecule. Its mechanism involves downregulation of pro-inflammatory cytokines such as TNF-α, IL-6, and IL-1β, primarily through inhibition of NF-κB signaling. This makes it a valuable candidate for formulations aimed at sensitive or reactive skin, as well as for research into inflammatory bowel diseases and other chronic inflammatory models.

LyvBio supplies KPV as a high-purity synthetic peptide, typically ≥98% as determined by HPLC. Each batch is rigorously tested for identity, purity, and residual solvents, ensuring consistent performance for both research and product development. The peptide is available in gram to kilogram quantities, with custom packaging options to suit various scale-up needs.

Product Overview & Composition

KPV is a linear tripeptide with the sequence H-Lys-Pro-Val-OH. The presence of proline introduces a conformational constraint that enhances resistance to enzymatic degradation, while the lysine residue contributes to water solubility and potential ionic interactions with biological membranes. The valine moiety adds hydrophobic character, influencing the peptide’s overall pharmacokinetic profile.

In its lyophilized form, KPV appears as a white to off-white powder. It is freely soluble in water and common polar solvents like dimethyl sulfoxide (DMSO) and methanol. For cell culture or formulation work, it is typically reconstituted in sterile water or phosphate-buffered saline (PBS). The peptide should be stored desiccated at -20°C to maintain stability over extended periods.

Key Applications

• Anti-inflammatory skincare: KPV is incorporated into creams, serums, and masks targeting redness, irritation, and sensitive skin. It helps modulate the skin’s inflammatory response without causing pigmentation.
• Research on inflammatory diseases: Used in studies exploring colitis, dermatitis, and other inflammatory conditions due to its ability to inhibit NF-κB and reduce cytokine production.
• Immunomodulatory formulations: Leveraged in products aimed at balancing immune responses in topical and injectable preparations.
• Wound healing: Investigated for its potential to accelerate tissue repair by controlling excessive inflammation.
• Cosmeceutical actives: Combined with other peptides and antioxidants to enhance overall skin health and resilience.

Quality & Standards

Packaging & Supply

• Packaging: Sealed glass vials or aluminum foil bags, suitable for long-term storage.
• MOQ: 1 gram for research quantities; bulk orders negotiable.
• Lead time: 3-5 business days (stock items)
• Documentation: COA, MSDS, TDS provided with each shipment.

Request For Quote

• LyvBio Co., Ltd. — Email: info@lyvbio.com