IGF1 LR-3

Synonyms: IGF-1 LR3, Long R3 IGF-1, Long Arginine 3 IGF-1, Insulin-like Growth Factor 1 LR3, LR3 IGF-1, Somatomedin C LR3, IGF1-LR3

Recombinant IGF-1 LR3 is a long-chain analogue of human insulin-like growth factor 1, engineered with an N-terminal extension and an arginine substitution at position 3. The modification reduces binding to IGF-binding proteins, which keeps more of the peptide available in free form in cell culture media. It is produced by recombinant expression in E. coli and supplied as a sterile-filtered lyophilized powder, typically at ≥98% purity by HPLC.

Buyers in bioprocessing and cell culture development source IGF-1 LR3 as a media supplement to support proliferation and scale-up of CHO, HEK293 and other mammalian cell lines. The peptide is also used in serum-free formulations where insulin or native IGF-1 alone does not deliver sufficient growth support. Each lot ships with a certificate of analysis confirming identity, purity and endotoxin level, and the powder is stable for long-term storage at -20°C.

Grade & Supply Forms

We supply research-grade and cell-culture-grade IGF-1 LR3, both produced under controlled fermentation and purification conditions. The standard format is a lyophilized powder in sealed vials, available in sizes from 1 mg to 1 g. For larger bioprocess campaigns, bulk quantities can be provided in single-use bags or as custom aliquots to match your media preparation workflow.

Purity is verified by RP-HPLC and mass spectrometry, with endotoxin testing available on request. The peptide is soluble in water and standard aqueous buffers, and we recommend reconstitution in sterile water or PBS at neutral pH for cell culture use. Avoid repeated freeze-thaw cycles; prepare single-use aliquots after reconstitution.

Applications & Formulation Use

IGF-1 LR3 is added to serum-free and chemically defined media for mammalian cell culture, particularly in bioprocessing for monoclonal antibody and recombinant protein production. It supports cell growth and productivity in CHO and HEK293 systems, often in combination with insulin, transferrin and other growth factors. Formulators also use it in primary cell culture and stem cell expansion protocols where consistent growth performance is critical.

In media development, the peptide is typically included at concentrations ranging from 10 to 100 ng/mL, depending on cell type and culture format. It is compatible with standard filtration and aseptic handling procedures. For research applications, it is used in studies of cell signaling, metabolism and proliferation, but the primary commercial demand comes from bioprocess media suppliers and CDMOs.

Bulk Packaging & Ordering

• Packaging: Lyophilized powder in sealed vials; bulk orders in single-use bags or custom aliquots
• MOQ: 1 mg for standard vials; 100 mg for bulk quantities
• Lead time: 3-5 business days (stock items)
• Documentation: COA, MSDS, TDS

Contact & Ordering Information

• Company: LyvBio Co., Ltd.
• Address: Room 5-0203, Courtyard 205, Lianhu District, Xi’an, Shaanxi, China
• Email: info@lyvbio.com
• Phone/WA: +86-182-9185-7498

send us your specification for a quotation.