HMB

Synonyms: β-Hydroxy β-methylbutyric acid, HMB, 3-Hydroxy-3-methylbutanoic acid, β-Hydroxyisovaleric acid, 3-Hydroxyisovaleric acid

HMB has become a staple in sports nutrition and healthy aging formulations, thanks to its well-documented role in muscle protein metabolism. As athletes and older adults alike seek to preserve lean mass, demand for this metabolite has surged across supplement, medical food, and clinical nutrition segments.

Chemically, HMB is a metabolite of the branched-chain amino acid leucine, produced endogenously via the oxidation of α-ketoisocaproate. It is found in small quantities in foods like alfalfa, catfish, and grapefruit, but commercial HMB is synthesized through chemical or biotechnological routes to achieve high purity.

LyvBio supplies HMB as a free acid and as calcium salt, with standard assay ≥98.0% (HPLC). Our material is manufactured under cGMP conditions, ensuring consistent quality for muscle health, recovery, and anti-catabolic applications.

Product Overview & Composition

HMB is a small, water-soluble molecule that acts as a signaling metabolite and precursor in protein synthesis pathways. It is available as a free acid (hygroscopic) or as calcium β-hydroxy-β-methylbutyrate (Ca-HMB), which offers better handling and stability. Both forms are used interchangeably in solid dosage forms, though Ca-HMB is preferred for tablets and capsules due to its non-hygroscopic nature.

Compositionally, HMB is identical to the naturally occurring metabolite, ensuring biological activity. Our product is free from major allergens and meets strict purity standards for heavy metals and microbial limits.

Key Applications

• Muscle health & recovery: Supports lean mass preservation and reduces exercise-induced muscle damage.
• Sports nutrition: Formulated in pre-workout, post-workout, and recovery beverages.
• Clinical nutrition: Used in medical foods for sarcopenia, cachexia, and age-related muscle loss.
• Animal health: Incorporated into livestock feed to improve growth and feed efficiency.
• Pharmaceutical research: Studied for its role in metabolic disorders and muscle-wasting conditions.

Quality & Standards

Packaging & Supply

• Packaging: 25 kg fiber drum with two food-grade PE liners, or customized packaging upon request.
• MOQ: 25 kg.
• Lead time: 3-5 business days (stock items)
• Documentation: COA, MSDS, TDS, and other regulatory documents available upon request.

Request For Quote

• LyvBio Co., Ltd. — Email: info@lyvbio.com