Estriol

Synonyms: 16α-Hydroxyestradiol, 1,3,5(10)-Estratriene-3,16α,17β-triol, E3, Follicular hormone, Oestriol

Estriol is a natural steroid hormone, specifically one of the three main estrogens produced by the human body. It is biosynthesized primarily during pregnancy by the placenta, and its levels rise significantly in the later stages of gestation. Since its isolation in the 1930s, estriol has been studied for its distinct biological profile, which differs from that of estrone and estradiol. Unlike its more potent counterparts, estriol exhibits a weaker binding affinity for estrogen receptors, a characteristic that has drawn interest in both pharmaceutical and clinical research settings.

Chemically, estriol is a C18 steroid with a phenolic A-ring and hydroxyl groups at positions 3, 16α, and 17β. This unique 16α-hydroxylation pattern is responsible for its relatively low estrogenic potency and its rapid clearance from the body. The compound is often produced synthetically from plant sterols or via microbial transformation for commercial use. In the pharmaceutical industry, estriol is used as an active pharmaceutical ingredient (API) in hormone replacement therapies and investigational products targeting menopausal symptoms, urogenital health, and certain dermatological conditions.

As a bulk ingredient, estriol is supplied in high-purity grades, typically ≥98.0% as determined by HPLC. It is available in kilogram to multi-kilogram quantities to meet the needs of formulators, contract manufacturers, and research organizations. Our production adheres to strict quality control measures, ensuring consistent particle size, low impurity profiles, and full documentation for regulatory submissions.

Function & Mechanism

• Selective estrogen receptor modulation: Binds to estrogen receptors with lower affinity than estradiol, producing a milder estrogenic response.
• Menopausal symptom relief: Helps alleviate hot flashes and vaginal dryness in hormone replacement therapy.
• Urogenital support: Promotes the health of the urinary and genital tissues, often used in topical formulations.
• Bone health: May contribute to the maintenance of bone mineral density, though with less potency than estradiol.
• Dermatological applications: Investigated for its effects on skin aging and collagen synthesis.

Source & Standardization

• Source: Synthetic, derived from plant sterols or via microbial transformation.
• Manufacturing: Multi-step chemical synthesis followed by purification and crystallization.
• Standardization: ≥98.0% (HPLC), with strict control of related substances.
• Forms: White to off-white crystalline powder.
• Applications: Pharmaceutical APIs, hormone replacement therapy, clinical research, cosmetic formulations.

Quality Specifications (QC Tests)

Bulk Supply & Documentation

• Monthly capacity: 50 kg
• Lead time: 3-5 business days
• Documentation: COA, MSDS, TDS available upon request
• Packaging: 1 kg, 5 kg, 25 kg in double-lined fiber drums

Frequently Asked Questions

What is the minimum order quantity (MOQ) for Estriol?

Our standard MOQ is 1 kg. For smaller quantities, please contact our sales team to discuss your specific needs.

How long does delivery take?

For stock items, delivery is typically 3-5 business days after order confirmation. We maintain sufficient inventory to ensure prompt shipment.

Do you provide a Certificate of Analysis (COA) and samples?

Yes, a COA is provided with every shipment. Samples are available upon request; please contact us for further details.

Contact & Ordering Information

• Company: LyvBio Co., Ltd.
• Address: Room 5-0203, Courtyard 205, Lianhu District, Xi’an, Shaanxi, China
• Email: info@lyvbio.com
• Phone: +86-29-65816888

send us your specification for a quotation.