Esculetin

Synonyms: Esculetin, 6,7-Dihydroxycoumarin, Cichorigenin, Aesculetin, Esculetol

Esculetin is a naturally occurring coumarin derivative characterized by a benzopyrone core with hydroxyl groups at the 6 and 7 positions. This dihydroxy substitution pattern imparts significant antioxidant and metal-chelating properties, distinguishing it from simple coumarins. The compound is found in various medicinal plants, including Fraxinus species (ash bark), Artemisia species, and Citrus fruits, and has been a subject of interest for its diverse pharmacological activities.

As a high-purity chemical reference, Esculetin (CAS 305-01-1) is supplied as a crystalline powder, typically with a purity of ≥98% (HPLC). It is widely employed in research settings to investigate its anti-inflammatory, antioxidant, and anti-proliferative effects, as well as in the development of nutraceutical and pharmaceutical formulations. Its role as a biochemical tool in studying enzyme inhibition and signal transduction pathways further underscores its value in life sciences.

For B2B buyers, consistent quality and reliable supply are paramount. Our Esculetin is produced under controlled conditions, with each batch rigorously tested to ensure compliance with the specified purity and physicochemical parameters. We provide comprehensive documentation, including COA, MSDS, and TDS, to support your quality assurance and regulatory needs.

Chemical Structure & Properties

Esculetin (6,7-dihydroxycoumarin) belongs to the coumarin family, which shares a common 1-benzopyran-2-one skeleton. The presence of two adjacent hydroxyl groups on the aromatic ring allows for efficient free radical scavenging and chelation of transition metal ions, contributing to its antioxidant capacity. The compound exhibits strong UV absorption with maxima around 340 nm, making it detectable by HPLC for precise quantification. Its moderate lipophilicity (log P ~1.3) facilitates cell membrane permeability, which is relevant for its bioactivity in cellular models.

Mechanism of Action

• Antioxidant activity: Donates hydrogen atoms to neutralize reactive oxygen species (ROS) and upregulates endogenous antioxidant enzymes such as superoxide dismutase (SOD) and catalase.
• Anti-inflammatory effects: Inhibits the activity of cyclooxygenase (COX) and lipoxygenase (LOX), reducing the synthesis of pro-inflammatory prostaglandins and leukotrienes.
• Enzyme inhibition: Suppresses tyrosinase activity, which is key in melanin biosynthesis, and modulates aldose reductase, relevant in diabetic complications.
• Cell signaling modulation: Interferes with NF-κB and MAPK pathways, thereby downregulating inflammatory cytokine expression.
• Antiproliferative action: Induces apoptosis in certain cancer cell lines by activating caspases and altering mitochondrial membrane potential.

Quality Specifications

Supply & Documentation

• Capacity: 500 kg per month, with scale-up capabilities for bulk orders.
• Lead time: 5–7 working days for standard quantities; custom requirements discussed on request.
• Documentation: COA, MSDS, TDS, and allergen statement provided with each shipment.
• Packaging: Available in 1 kg, 5 kg, and 25 kg fiber drums with inner double polyethylene bags; custom packaging available.

Request For Quote

• Our Address: 280 Main Street, Xian, Shaanxi, China
• LyvBio Co., Ltd. — Email: info@lyvbio.com