Dipeptide Diaminobutyroyl Benzylamide Diacetate

Synonyms: Dipeptide Diaminobutyroyl Benzylamide Diacetate, DAB-Benzylamide Diacetate, SYN-AKE, Dipeptide Diaminobutyroyl Benzylamide Diacetate (Cosmetic Peptide)

Dipeptide Diaminobutyroyl Benzylamide Diacetate is a synthetic tripeptide that acts as a reversible antagonist of the nicotinic acetylcholine receptor at the neuromuscular junction. Its molecular design incorporates a diaminobutyroyl residue and a benzylamide moiety, which together enhance binding affinity and stability. By blocking acetylcholine binding, it reduces muscle contractions that lead to expression lines, offering a topical alternative to botulinum toxin.

This peptide is manufactured via solid-phase peptide synthesis, followed by purification and conversion to the diacetate salt to improve water solubility. It is supplied as a white to off-white powder with high purity, typically ≥98% as determined by HPLC. The material is stable under recommended storage conditions and is compatible with a wide range of cosmetic formulations.

In cosmetic science, Dipeptide Diaminobutyroyl Benzylamide Diacetate is used in anti-aging and anti-wrinkle products, particularly those targeting expression lines on the forehead and around the eyes. It is also employed in research settings to study neuromuscular communication and skin physiology.

Chemical Structure & Properties

The molecule consists of a dipeptide backbone with a diaminobutyroyl group and a benzylamide cap. The diacetate salt form enhances aqueous solubility, making it suitable for incorporation into serums, creams, and gels. Its low molecular weight allows for efficient skin penetration, and the benzylamide group contributes to lipophilic character, balancing the overall polarity.

Mechanism of Action

• Nicotinic acetylcholine receptor antagonism: Competitively binds to the receptor, preventing acetylcholine from initiating muscle contraction.
• Reduction of muscle micro-contractions: By inhibiting receptor activation, it minimizes repetitive muscle movements that cause dynamic wrinkles.
• Skin smoothing effect: Clinically shown to reduce the depth of expression lines with regular use.
• Non-invasive alternative: Provides a topical approach to modulating neuromuscular activity without injections.

Quality Specifications

Supply & Documentation

• Capacity: 500 kg per month
• Lead time: 3-5 business days (stock items)
• Documentation: COA, MSDS, TDS available upon request
• Packaging: 1 kg, 5 kg, 10 kg in aluminum foil bags or fiber drums

Request For Quote

• LyvBio Co., Ltd. — Email: info@lyvbio.com