Copper Tripeptide-1 (GHK-Cu)

Synonyms: GHK-Cu, Copper Peptide-1, Copper Tripeptide-1, Glycyl-L-histidyl-L-lysine copper complex, Copper Glycyl-Histidyl-Lysine, GHK Copper

Copper Tripeptide-1, also known as GHK-Cu, is a synthetic tripeptide complexed with copper(II) ions. Its sequence—glycyl-L-histidyl-L-lysine—was first isolated from human plasma and later identified as a natural component of wound healing and tissue remodeling processes. The copper ion is chelated by the histidine imidazole and the α-amino group of the peptide, giving the molecule its characteristic blue color and distinct biochemical activity.

As a cosmetic and pharmaceutical ingredient, GHK-Cu has gained significant traction in anti-aging, skin repair, and hair growth formulations. It is also a subject of ongoing research in regenerative medicine, where its ability to modulate collagen synthesis, angiogenesis, and inflammatory pathways is being explored. The material is typically supplied as a high-purity synthetic peptide with a copper content of approximately 15-16% (w/w), ensuring consistent performance in topical and injectable applications.

Function

• Collagen and elastin stimulation: Upregulates collagen I, III, and elastin production in fibroblasts, improving skin firmness and elasticity.
• Antioxidant and anti-inflammatory: Copper ions scavenge free radicals and modulate inflammatory cytokines, reducing oxidative stress in tissues.
• Wound healing and tissue repair: Promotes angiogenesis and extracellular matrix remodeling, accelerating repair processes.
• Hair growth support: Enhances follicle size and hair shaft thickness by stimulating dermal papilla cells.
• Copper delivery: Acts as a safe, bioavailable copper carrier for enzymatic and cellular functions.

Source & Standardization

• Source: Synthetic solid-phase peptide synthesis
• Complexation: Copper(II) chloride or copper(II) acetate used to form the chelate
• Purification: HPLC purification to ≥98% purity
• Standardization: Copper content 15.5-16.5% (w/w) by ICP-MS or atomic absorption
• Forms: Blue to violet-blue crystalline powder
• Applications: Cosmeceuticals, wound care, hair care, research

Specifications

Documentation & Supply

• Packaging: 1 g, 5 g, 10 g, 50 g, 100 g in amber glass vials; custom packaging available.
• MOQ: 1 g for standard packs; 10 g for bulk orders.
• Lead time: 3-5 business days for in-stock items; 2-3 weeks for custom synthesis.
• Documentation: COA, MSDS, TDS provided with each shipment.
• Storage: Store at -20°C, protected from light and moisture.

Request For Quote

• LyvBio Co., Ltd. — Email: info@lyvbio.com