Cooling Agent WS-5

Synonyms: N-[(1R,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexyl]acetamide, WS-5, N-[(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl]acetamide, Acetic acid (1R,2S,5R)-2-isopropyl-5-methylcyclohexylamide, N-[(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl]acetamide

Cooling Agent WS-5 is a synthetic cyclohexane carboxamide derivative, structurally related to menthol but with a modified carboxamide group. The molecule features a cyclohexane ring with an isopropyl and a methyl substituent in specific stereochemical configuration, and an acetamide moiety attached to the ring. This unique structure confers a cooling effect without the typical minty odor or taste associated with menthol.

WS-5 is a highly potent cooling agent belonging to the “WS” series, which includes WS-3, WS-12, and WS-23. It is synthesized through a multi-step process starting from menthol or its derivatives, resulting in a white crystalline powder with a purity typically ≥99%. The compound is widely used in food, pharmaceutical, and cosmetic industries as a cooling agent, flavor enhancer, and sensory additive.

In B2B applications, WS-5 is valued for its intense and long-lasting cooling sensation, which is approximately 2.5 times stronger than menthol and 1.5 times stronger than WS-3. It is employed in products such as chewing gum, confectionery, oral care products, topical analgesics, and e-liquids, where a cooling effect without a strong mint flavor is desired.

Chemical Structure & Properties

WS-5, or N-[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl]acetamide, has a molecular formula of C13H25NO and a molecular weight of 211.34 g/mol. It appears as a white crystalline powder with a purity of at least 99%. The compound is practically insoluble in water but readily soluble in organic solvents such as ethanol and propylene glycol. Its melting point is typically between 95-100°C, and it exhibits high thermal stability, making it suitable for various processing conditions.

Mechanism of Action

• TRPM8 activation: WS-5 selectively activates the TRPM8 receptor, a cold-sensing ion channel, without affecting other sensory receptors. This leads to a cooling sensation without irritation.
• Prolonged effect: Due to its lipophilic nature, WS-5 penetrates cell membranes and remains active for extended periods, providing a long-lasting cooling effect.
• No odor or taste: Unlike menthol, WS-5 does not impart a minty odor or taste, making it ideal for applications where a neutral sensory profile is required.
• Low volatility: WS-5 has low volatility, which means it does not evaporate quickly and maintains its cooling effect over time.

Quality Specifications

Supply & Documentation

• Capacity: 20 metric tons per month
• Lead time: 3-5 business days (stock items)
• Documentation: COA, MSDS, TDS available upon request
• Packaging: 25 kg fiber drum with double polyethylene liner, or as per customer requirements

Request For Quote

• LyvBio Co., Ltd. — Email: info@lyvbio.com