Cooling Agent WS-23

Synonyms: N,2,3-Trimethyl-2-isopropylbutanamide, WS-23, Cooling Agent 23, N-Isopropyl-N,2,3-trimethylbutanamide, 2-Isopropyl-N,2,3-trimethylbutyramide

Cooling Agent WS-23 is a synthetic alkylamide built around a trimethyl-substituted butanamide backbone, and it belongs to the same functional family as the better-known WS-3 and WS-5. Unlike menthol, it carries no minty aroma or bitter edge; the molecule delivers a clean, high-impact cooling sensation by acting directly on the TRPM8 and TRPA1 cold receptors, without the olfactory signature that limits menthol in flavored systems.

Chemically, WS-23 is distinguished by its compact branched structure and the absence of a cyclohexane ring, which sets it apart from the menthane carboxamide derivatives. This structural difference translates into practical behavior: the material is essentially odorless, thermally stable, and slow to volatilize, so the cooling effect persists well beyond what menthol can offer. It also shows good compatibility with a wide range of flavor and fragrance bases, which is why formulators reach for it when a neutral cooling profile is required.

Because it is potent, WS-23 is typically dosed at low percentages, often between 0.02% and 0.2% depending on the matrix. It is supplied as a high-purity crystalline solid, generally ≥99% by GC, and is widely used in oral care, confectionery, chewing gum, beverages, nicotine and cannabis vapor products, topical gels, and dermal patches. For B2B buyers, the key advantages are consistent assay, low odor, and reliable solubility in the carriers commonly used on production lines.

Function

• Cooling effect: Activates TRPM8 cold receptors to produce a sustained, menthol-free cooling sensation.
• Flavor neutral: Adds no minty or bitter notes, so it will not interfere with delicate flavor systems.
• Thermal stability: Withstands typical processing temperatures in confectionery and vaping applications.
• Low volatility: Remains active in the matrix longer than menthol, extending perceived freshness.
• Formulation flexibility: Dissolves readily in ethanol, propylene glycol, and lipophilic carriers.

Source & Standardization

• Source: Synthetic, produced via amidation of 2,3-dimethyl-2-isopropylbutanoic acid derivatives.
• Purification: Crystallization and vacuum distillation to reach high isomeric purity.
• Standardization: ≥99.0% by GC; identity confirmed by IR and GC retention time.
• Forms: White crystalline powder or prills, depending on customer requirement.
• Applications: Oral care, confectionery, chewing gum, beverages, e-liquids, topical analgesics, patches.

Specifications

Documentation & Supply

• Monthly capacity: 10–15 MT, with scalable batch production.
• Lead time: 3-5 business days (stock items)
• Documentation: COA, MSDS, TDS, and regulatory support on request.
• Packaging: 25 kg fiber drum with inner PE liner; custom packaging available.
• Storage: Keep tightly sealed in a cool, dry place away from direct sunlight.

Request For Quote

• LyvBio Co., Ltd. — Email: info@lyvbio.com