Colchicoside

Synonyms: Colchicoside, Colchicine glucoside, Colchicine-3-glucoside

Colchicoside is a naturally occurring glycosylated derivative of colchicine, a well-known alkaloid found in plants of the genus Colchicum. In recent years, it has attracted growing interest from pharmaceutical researchers and formulators exploring its potential beyond the traditional use of colchicine, particularly for its anti-inflammatory and antiproliferative properties. As a more water-soluble analog, colchicoside offers a distinct advantage in formulation development, making it a valuable compound for both analytical studies and therapeutic applications.

Colchicoside is isolated primarily from the seeds of Colchicum autumnale, a plant long recognized in traditional medicine for the treatment of gout and inflammatory conditions. The compound is a colchicine molecule linked to a glucose moiety via a glycosidic bond, which modifies its pharmacokinetics and solubility profile. This structural modification is of particular interest to researchers investigating ways to improve the bioavailability and safety margin of colchicine-based therapies.

LyvBio supplies colchicoside with a purity of ≥98% (HPLC), ensuring reliable performance in both research and scale-up applications. Our product is rigorously tested to meet strict quality standards, and we provide comprehensive documentation to support your development needs. Whether you are conducting preclinical studies or developing novel formulations, our colchicoside is designed to deliver consistent results.

Product Overview & Composition

Colchicoside is a glycosylated alkaloid, structurally characterized by a colchicine core attached to a glucose molecule. The presence of the sugar moiety significantly enhances its water solubility compared to the parent colchicine, which is a key factor in its handling and formulation. The compound is biosynthetically derived from colchicine in Colchicum species and can be extracted and purified to high concentrations for commercial use.

At LyvBio, we focus on producing colchicoside with high purity and batch-to-batch consistency. Our manufacturing process involves carefully controlled extraction and purification steps to ensure the final product meets the specified 98% HPLC requirement. Each batch is analyzed to confirm identity, purity, and absence of significant impurities, providing researchers with a dependable material for their work.

Key Applications

• Anti-inflammatory research: Colchicoside is studied for its potential to modulate inflammatory pathways, similar to colchicine, with potentially improved tolerability.
• Antiproliferative studies: Its activity against cell proliferation makes it a candidate for cancer research, particularly in combination with other agents.
• Pharmaceutical formulation: The improved solubility profile allows for the development of injectable or oral formulations that may be more bioavailable than colchicine alone.
• Analytical standards: As a high-purity reference standard, colchicoside is used in quality control and method development for alkaloid analysis.
• Biochemical studies: Researchers use colchicoside to study tubulin binding and microtubule dynamics, given its structural relationship to colchicine.

Quality & Standards

Packaging & Supply

• Packaging: Available in 1 kg, 5 kg, and 25 kg drums, with custom packing options on request.
• MOQ: 1 kg for initial orders, flexible for bulk quantities.
• Lead time: Typically 5-7 days after confirmation for stock items; larger orders may require 2-3 weeks.
• Documentation: COA, MSDS, and TDS are provided with every shipment, ensuring full traceability and compliance.

Request For Quote

• Our Address: 280 Main Street, Xian, Shaanxi, China
• LyvBio Co., Ltd. — Email: info@lyvbio.com