Clascoterone

Synonyms: Cortexolone 17α-propionate, 17α-Propionyloxy-11-deoxycortisol, 11-Deoxycortisol 17-propionate, Clascoteroneum

17alpha-propionate;17alpha-propio17-(1-oxopropoxy)pregn-4-ene-3,20-dione;CB-03-0117alpha-propionate;Cortexolone17-alpha-propionate;17alpha-propiChemicalbookonate(CB-03-01);21-Hydroxy-17-(1-oxopropoxy)pregn-4-ene-3,20-dione;Clascoterone;CB-03-01;CORTEXOLONE17Α-PROPIONATE;CORTEXOLONE17ALPHA-PROPIONATE

Clascoterone has rapidly become a molecule of interest in dermatology, particularly for its ability to target androgen-driven skin conditions without systemic hormonal effects. As the first topical androgen receptor inhibitor approved for acne, it has opened new formulation avenues for brands looking to address sebum regulation and inflammatory pathways locally. The ingredient is now commonly evaluated in creams, gels, and serums aimed at hormonal acne and androgenetic alopecia.

Chemically, Clascoterone is a synthetic steroid derivative—specifically the 17α-propionate ester of cortexolone (11-deoxycortisol). This structural modification enhances its lipophilicity and skin penetration while minimizing systemic absorption. It is manufactured through multi-step steroid synthesis, yielding a highly pure crystalline solid that meets pharmacopeial standards.

LyvBio supplies Clascoterone at ≥99% purity by HPLC, a grade suitable for topical formulation development and clinical research. The product is characterized by a single predominant peak in HPLC analysis, ensuring consistent biological activity and formulation stability.

Product Overview & Composition

Clascoterone is a white to off-white crystalline powder, practically insoluble in water but soluble in organic solvents such as ethanol and dimethyl sulfoxide. Its molecular formula is C24H34O5, with a molecular weight of 402.52 g/mol. The compound is stable under recommended storage conditions and is typically micronized to a fine particle size to facilitate dispersion in topical bases.

Applications & Product Lines

• Topical acne treatments: Used as the active pharmaceutical ingredient in creams and gels for androgen-dependent acne vulgaris.
• Hair care formulations: Incorporated into scalp serums and foams targeting androgenetic alopecia and sebum control.
• Dermatological research: Studied for its selective androgen receptor modulating effects in skin models.
• Compounding pharmacies: Utilized in custom topical preparations for patients requiring personalized acne therapy.

Quality Control Standards

Bulk Packaging & Supply

• Packaging: 100 g, 500 g, 1 kg in amber glass bottles or double-lined polyethylene bags, sealed in aluminum foil pouches.
• MOQ: 100 g
• Lead time: 3-5 business days (stock items)
• Documentation: COA, MSDS, TDS available upon request.

Frequently Asked Questions

What is the minimum order quantity (MOQ) for Clascoterone?

The MOQ is 100 g. For larger quantities, please contact our sales team for pricing and availability.

How long does delivery take?

For stock items, delivery is 3-5 business days after order confirmation. We ship globally via express couriers.

Do you provide a Certificate of Analysis (COA) and samples?

Yes, a COA is available for each batch. We can provide samples (typically 10-20 g) for evaluation; sample delivery takes 1-2 days after request.

Contact & Ordering Information

• Company: LyvBio Co., Ltd.
• Address: Room 5-0203, Courtyard 205, Lianhu District, Xi’an, Shaanxi, China
• Email: info@lyvbio.com
• Phone: +86-29-65816888

send us your specification for a quotation.