Cinchonine

Cinchonine (CAS 118-10-5) is a cinchona alkaloid isolated from the bark of Cinchona species, structurally related to quinine but differing in the stereochemistry at C8 and C9. This product is supplied as a white to off-white crystalline powder with ≥98% purity by HPLC, suitable for pharmaceutical research, asymmetric synthesis, and as a chiral resolving agent.

With a well-documented profile in stereoselective transformations, cinchonine is a practical choice for process chemists developing enantioselective methodologies. Its availability in multi-kilogram quantities, paired with rigorous quality control, supports both lab-scale development and production-scale applications.

Synonyms: (9S)-Cinchonan-9-ol, (8S,9R)-Cinchonan-9-ol, Cinchonine base, (8S,9R)-6′-Methoxycinchonan-9-ol? (No, that’s quinidine), but here: (9S)-Cinchonan-9-ol, Cinchonine, (8S,9R)-Cinchonan-9-ol, (+)-Cinchonine

Applications

• Chiral ligand and organocatalyst in asymmetric synthesis (e.g., Sharpless dihydroxylation, Michael additions)
• Resolution agent for racemic acids and bases in preparative chemistry
• Building block for the synthesis of antimalarial and antiarrhythmic drug candidates
• Reference standard in pharmacopoeial testing and analytical method development

Quality & Documentation

Every batch is tested for assay (HPLC ≥98%), melting point, loss on drying (≤0.5%), residue on ignition (≤0.1%), and heavy metals (≤10 ppm). A full COA, MSDS, and TDS are provided with each shipment; stability data and impurity profiles are available upon request.

Packaging & Supply

Standard packaging is 100 g, 500 g, and 1 kg in sealed foil bags or glass bottles. Bulk quantities (5 kg and above) are supplied in fiber drums. In-stock items ship within 3-5 business days. MOQ is 100 g for research quantities, with flexible scale-up options. For pricing, samples, or bulk orders, contact our sales team.

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