Benzgalantamine

Synonyms: Benzgalantamine, 6-O-Benzylgalanthamine, (4aS,6R,8aS)-6-O-Benzyl-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol

In the evolving landscape of cognitive health, the demand for innovative acetylcholinesterase inhibitors has surged. Benzgalantamine has emerged as a compound of significant interest, particularly in the development of next-generation nootropics and therapeutics targeting neurodegenerative conditions. Its unique structural modification offers potential advantages in modulating cholinergic pathways, making it a focal point for research and product development in the pharmaceutical and nutraceutical sectors.

Benzgalantamine is a synthetic derivative of galanthamine, a natural alkaloid found in plants of the Amaryllidaceae family, such as snowdrop and daffodil. The benzyl group at the 6-O position enhances lipophilicity, potentially improving blood-brain barrier penetration and altering pharmacokinetic profiles. This modification distinguishes it from its parent compound, offering new avenues for formulation and efficacy studies.

LyvBio supplies Benzgalantamine with a purity of ≥98.0% (HPLC), ensuring consistent quality for research and development. Our product is synthesized under strict conditions, with comprehensive documentation to support regulatory and quality requirements. It is available in various quantities to accommodate projects from early-stage screening to pilot-scale production.

Product Overview & Composition

Benzgalantamine is a benzyl ether derivative of galanthamine, characterized by the addition of a benzyl group to the oxygen at the 6-position of the galanthamine scaffold. This structural change increases the molecule’s lipophilicity, which may influence its interaction with acetylcholinesterase and its distribution in biological systems. The compound is synthesized through a multi-step process starting from galanthamine, involving protection, benzylation, and deprotection steps. Each batch is controlled for identity, purity, and residual solvents to meet stringent specifications.

As a research chemical, Benzgalantamine is intended for laboratory and pilot-scale use. It is not approved for human consumption, and its handling should follow standard safety protocols for potent compounds. LyvBio provides detailed analytical data, including NMR and mass spectra, to confirm structure and purity.

Key Applications

• Alzheimer’s disease research: Investigated for its potential to inhibit acetylcholinesterase and modulate nicotinic receptors, offering a dual mechanism that may enhance cognitive function.
• Nootropic formulations: Explored as a component in cognitive enhancement products, leveraging its improved lipophilicity for better brain bioavailability.
• Pharmacological studies: Used as a reference standard in comparative studies of cholinesterase inhibitors and for studying structure-activity relationships.
• Drug delivery research: Utilized in the development of novel delivery systems, such as nanoparticles or prodrugs, to target the central nervous system.
• Analytical method development: Serves as a standard for HPLC, LC-MS, and other analytical techniques in pharmacokinetic and metabolic studies.

Quality & Standards

Packaging & Supply

• Packaging: 1 kg, 5 kg, 10 kg in aluminum foil bags or fiber drums, with inner liners to prevent moisture and light exposure.
• MOQ: 100 grams, with flexibility for research-scale orders.
• Lead time: 3-5 business days (stock items)
• Documentation: COA, MSDS, TDS, and custom analytical reports (e.g., NMR, HPLC) provided with each shipment.
• Storage: Store at 2-8°C, protected from light and moisture. Retest date is typically 24 months from the date of manufacture.

Request For Quote

• LyvBio Co., Ltd. — Email: info@lyvbio.com