Avanafil

Synonyms: TA-1790, 4-[(3-Chloro-4-methoxybenzyl)amino]-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide, Avanafilum, Stendra, Spedra, TA 1790

Avanafil is a highly selective phosphodiesterase type 5 (PDE5) inhibitor developed for the treatment of erectile dysfunction. It is a synthetic small-molecule API manufactured under cGMP conditions, available as a white to off-white crystalline powder with an assay of ≥99.0% by HPLC.

Known commercially as Stendra and Spedra, Avanafil is distinguished by its rapid onset of action and high selectivity for PDE5 over other phosphodiesterase isoenzymes, which translates into a favorable side-effect profile. As a bulk API, it serves formulators developing oral solid dosage forms, including immediate-release tablets and orally disintegrating formulations.

Product Highlights

• High purity: ≥99.0% by HPLC, with tight control on related substances and residual solvents.
• Selective PDE5 inhibition: High selectivity over PDE6 and PDE11, potentially reducing visual and musculoskeletal side effects.
• Rapid onset: Peak plasma concentrations reached within 30–45 minutes in clinical studies.
• Regulatory support: Full documentation package including COA, MSDS, TDS, and cGMP manufacturing statements.
• Scalable supply: Commercial-scale production capacity to support both clinical and commercial needs.

Applications & Formulation Use

• Oral tablets for erectile dysfunction, including immediate-release and orodispersible dosage forms.
• Fixed-dose combination products requiring a fast-acting PDE5 inhibitor.
• Reference standard and analytical method development.
• Clinical research and bioequivalence studies.

Quality Specifications (QC Tests)

Bulk Supply & Ordering

• Packaging: 25 kg fiber drums with double polyethylene liners, or as per customer request.
• MOQ: 1 kg for stock items; 25 kg for custom packaging.
• Lead time: 3-5 business days for stock items.
• Documentation: COA, MSDS, TDS, and cGMP statement provided with each shipment.

Frequently Asked Questions

What is the minimum order quantity (MOQ) for Avanafil?

Our standard MOQ is 1 kg for stock items. For custom packaging or larger quantities, the MOQ is 25 kg. We can accommodate smaller quantities for research and development upon request.

What is the delivery time?

For stock items, the lead time is 3-5 business days from order confirmation. We ship globally via express couriers and air freight.

Do you provide a Certificate of Analysis (COA) and samples?

Yes, a COA is provided with every shipment. Samples for analytical evaluation are available upon request; sample dispatch typically takes 1-2 days after approval.

Contact & Ordering Information

• Company: LyvBio Co., Ltd.
• Address: Room 5-0203, Courtyard 205, Lianhu District, Xi’an, Shaanxi, China
• Email: info@lyvbio.com
• Phone: +86-29-65816888

send us your specification for a quotation.