Acetyl Tetrapeptide-2

Synonyms: Acetyl Tetrapeptide-2, Acetyl-lysyl-valyl-lysyl-arginine, Acetyl-KVKR, Acetyl Tetrapeptide-2 (INCI)

Acetyl Tetrapeptide-2 is a synthetic tetrapeptide featuring the sequence acetyl-lysyl-valyl-lysyl-arginine. The N-terminal acetyl group enhances stability against enzymatic degradation, while the C-terminal arginine contributes a net positive charge that facilitates interaction with cellular membranes. This structural design allows the peptide to remain active in topical formulations and cell culture media, making it a valuable tool for research on skin aging and extracellular matrix regulation.

First introduced in the early 2000s, Acetyl Tetrapeptide-2 is produced through solid-phase peptide synthesis and subsequent acetylation. It is commercially available as a high-purity powder, typically ≥98% as determined by HPLC. The peptide is supplied in research-grade and cosmetic-grade qualities, with the latter conforming to INCI nomenclature and meeting the requirements of the personal care industry.

In the realm of dermatological research, Acetyl Tetrapeptide-2 has been investigated for its potential to modulate collagen synthesis and improve skin firmness. Its mechanism involves the upregulation of key extracellular matrix components, such as collagen I and III, and the inhibition of matrix metalloproteinases. These properties make it a subject of interest for formulators developing anti-aging and skin-repair products. Additionally, its compatibility with a range of cosmetic ingredients supports its use in serums, creams, and emulsions.

Chemical Structure & Properties

Acetyl Tetrapeptide-2 is a linear tetrapeptide with the sequence Lys-Val-Lys-Arg, where the N-terminus is acetylated. The molecular formula is C₂₅H₄₆N₈O₇, and the molecular weight is approximately 558.7 g/mol. The presence of multiple basic amino acids (lysine and arginine) gives the peptide a high isoelectric point and a net positive charge at physiological pH, which can influence its solubility and interaction with negatively charged surfaces. The acetyl group at the N-terminus protects against exopeptidase cleavage, enhancing stability in formulation. The peptide is freely soluble in water and polar organic solvents, and it is typically supplied as a white to off-white powder. It should be stored desiccated at -20°C to maintain long-term stability.

Mechanism of Action

• Collagen synthesis: Acetyl Tetrapeptide-2 has been shown to stimulate the production of collagen I and III in fibroblasts, potentially through activation of the TGF-β signaling pathway.
• MMP inhibition: It may reduce the activity of matrix metalloproteinases (MMPs), enzymes that degrade collagen and other extracellular matrix proteins, thereby helping to maintain skin integrity.
• Elastin promotion: Studies suggest that the peptide can upregulate elastin synthesis, contributing to skin elasticity and firmness.
• Anti-inflammatory effects: The arginine residue may modulate inflammatory responses by interfering with cytokine signaling, although this mechanism is less characterized.
• Cellular communication: As a signaling peptide, it can influence keratinocyte-fibroblast crosstalk, promoting a more youthful extracellular matrix environment.

Quality Specifications

Supply & Documentation

• Capacity: Monthly production capacity of 10 kg, with scalable synthesis for larger quantities.
• Lead time: 3-5 business days (stock items)
• Documentation: Certificate of Analysis (COA), Material Safety Data Sheet (MSDS), Technical Data Sheet (TDS), and additional regulatory support upon request.
• Packaging: Available in 1 g, 10 g, 100 g amber glass vials or bulk containers, sealed under argon for stability.
• Shipping: Shipped at ambient temperature with desiccant; expedited shipping available for temperature-sensitive orders.

Request For Quote

• LyvBio Co., Ltd. — Email: info@lyvbio.com