Acetyl Hexapeptide-8

Synonyms: Acetyl Hexapeptide-8, Acetyl Hexapeptide-3, Argireline, Acetyl Glutamyl Heptapeptide-3, Acetyl Hexapeptide-8 (INCI), Pentapeptide-3, Acetyl Hexapeptide-8 Acetate

Acetyl Hexapeptide-8 is a synthetic peptide composed of six amino acids (glutamic acid, glutamine, methionine, and arginine) with an acetyl group at the N-terminus. This modification enhances stability and skin penetration. The peptide is known for its ability to inhibit neurotransmitter release, thereby reducing muscle contractions that lead to facial wrinkles. It is widely used in cosmetic formulations as a safer alternative to botulinum toxin.

Chemical Structure & Properties

Acetyl Hexapeptide-8 is a linear peptide with the sequence Acetyl-Glu-Glu-Met-Gln-Arg-Arg-NH2. It has a molecular weight of approximately 889 Da and is highly hydrophilic due to the presence of multiple charged amino acids. The acetyl group at the N-terminus protects against enzymatic degradation, while the C-terminal amidation enhances stability. The peptide is soluble in water and physiological buffers, and it is typically stable at neutral pH, though it may degrade under extreme pH or high temperatures.

Mechanism of Action

• SNARE complex inhibition: Acetyl Hexapeptide-8 competes with SNAP-25 for incorporation into the SNARE complex, preventing vesicle fusion and neurotransmitter release.
• Reduction of acetylcholine release: By interfering with SNARE formation, it decreases calcium-dependent exocytosis of acetylcholine at the neuromuscular junction.
• Muscle relaxation: The reduced neurotransmitter release leads to diminished muscle fiber contraction, softening expression lines.
• Topical anti-aging: When applied to the skin, it penetrates the stratum corneum and acts on underlying muscles to reduce dynamic wrinkles.

Quality Specifications

Supply & Documentation

• Capacity: 50 kg per month
• Lead time: 3-5 business days (stock items)
• Documentation: COA, MSDS, TDS available upon request
• Packaging: 1 g, 10 g, 100 g in amber glass vials or as per customer requirements

Request For Quote

• LyvBio Co., Ltd. — Email: info@lyvbio.com