Acetyl Hexapeptide-38

Synonyms: Acetyl Hexapeptide-38, N-Acetyl-L-prolyl-L-prolyl-L-tyrosyl-L-leucyl-L-prolyl-L-proline, Ac-Pro-Pro-Tyr-Leu-Pro-Pro-OH

Acetyl Hexapeptide-38 is a synthetic hexapeptide composed of six amino acids—proline, proline, tyrosine, leucine, proline, and proline—with an acetyl group capping the N-terminus. This acetylation enhances its stability against enzymatic degradation, making it more resistant to skin peptidases. The sequence features two proline pairs, which contribute to its rigid, cyclic structure and influence its interaction with collagen receptors.

This peptide is primarily used in anti-aging cosmetics and topical formulations. It acts as a signaling peptide, stimulating collagen synthesis and improving skin elasticity.

Its small molecular weight allows for good skin penetration, while the acetyl group helps maintain its bioactivity. In vitro studies suggest it can modulate fibroblast activity, leading to increased production of collagen I and III.

For formulators, Acetyl Hexapeptide-38 offers a stable, water-soluble peptide with documented efficacy. It is typically incorporated into serums, creams, and lotions at concentrations ranging from 1% to 5%. Given its growing popularity in dermo-cosmetics, it is a valuable addition to products targeting fine lines, wrinkles, and skin firmness.

Chemical & Properties

The peptide has a molecular formula of C34H54N6O8 and a molecular weight of 674.83 g/mol. It is a white to off-white powder, freely soluble in water and most polar solvents.

The presence of two proline residues in tandem creates a turn in the peptide backbone, which is crucial for its receptor binding and collagen-stimulating activity.

Quality Specifications

Supply & Documentation

• Capacity: 10 kg per month, scalable.
• Lead time: 5-7 business days for standard orders.
• Documentation: COA, MSDS, TDS, HPLC chromatogram available on request.
• Packaging: Sealed double polyethylene bags inside aluminum foil bag, 5g, 10g, 100g, 1kg options.

Request For Quote

• Our Address: 280 Main Street, Xian, Shaanxi, China
• LyvBio Co., Ltd. — Email: info@lyvbio.com