Ceftriaxone Sodium

Synonimy: Ceftriaxone sodium, Sodium ceftriaxone, 74578-69-1, (6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid disodium salt, Ceftriaxone disodium salt

Ceftriaxone sodium is a third-generation cephalosporin antibiotic supplied as a sterile or non-sterile powder for further processing into injectable formulations. It is manufactured through a multi-step synthesis starting from 7-ACA, with the final product isolated as the disodium salt to ensure water solubility.

Commercial material is typically offered at high purity, with assay values of 84.0% or higher on a dried basis. The powder is hygroscopic and sensitive to light and heat, so it is handled under controlled conditions to maintain stability. Bulk buyers specify the grade based on intended use—sterile for direct fill-finish, non-sterile for oral or topical preparations.

Most volume goes into sterile injectable lines for human use, where ceftriaxone sodium is formulated as a lyophilized powder or a ready-to-use solution. It also appears in veterinary injectables and in some oral suspensions, though the latter is less common due to poor oral absorption. The compound is compatible with standard excipients used in parenteral formulations.

Applications & Formulation Use

Ceftriaxone sodium is primarily used in the production of sterile injectable antibiotics, typically as a 1 g or 2 g vial or as a premixed solution. Formulators combine it with pH adjusters and bulking agents for lyophilization, ensuring the reconstituted solution meets injection standards. Veterinary medicine also accounts for a share of demand, especially in large-animal injectables where broad-spectrum activity is required.

In oral dosage forms, ceftriaxone sodium is rarely used because of low bioavailability, but it can be found in some specialty suspensions for pediatric or geriatric use. The powder’s high water solubility simplifies compounding into liquid formulations, although stability in solution is limited and requires careful handling.

Sourcing & Production

Production starts with 7-aminocephalosporanic acid (7-ACA), which undergoes sequential acylation and substitution reactions to build the ceftriaxone core. The final sodium salt is formed by adjusting pH with sodium hydroxide or sodium carbonate, then crystallized and dried. Manufacturing sites are predominantly located in China and India, with capacities aligned to global pharmacopeial standards.

Our ceftriaxone sodium is produced under GMP conditions and is available in both sterile and non-sterile grades. The non-sterile grade is suitable for further processing, while the sterile grade is ready for aseptic filling. Each batch is tested for identity, assay, and related substances before release.

Bulk Supply & Documentation

• Opakowanie: 5 kg, 10 kg, 25 kg net in fiber drums with double polyethylene liners
• MOQ: 1 kg
• Czas realizacji: 3–5 dni roboczych (towary dostępne w magazynie)
• Dokumentacja: COA and MSDS with every shipment

Contact & Ordering Information

• Company: LyvBio Co., Ltd.
• Address: Room,5-0203, Unit 5, Beiyuanmen Street,Xi’an,Shaanxi,China
• Email: info@lyvbio.com
• Phone/WA: +86-182-9185-7498

send us your specification for a quotation.