| 제품명 | Aniracetam |
| CAS 번호 | 72432-10-1 |
| 분자식 | C₁₂H₁₃NO₃ |
| 분자량 | 219.24 g/mol |
| 외관 | 흰색에서 미백색의 결정성 분말 |
| Assay (HPLC) | ≥ 99.0% |
| Melting Point | 121–124°C |
| 건조 손실 | ≤ 0.5% |
| Residue on Ignition | ≤ 0.1% |
| 중금속 | 10 ppm 이하 |
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Aniracetam is a fat-soluble nootropic compound belonging to the racetam family. It is a cognitive enhancer known for its unique dual mechanism of action—modulating both AMPA receptors (glutamatergic) and nicotinic acetylcholine receptors (cholinergic), while also influencing serotonin and dopamine pathways.
Aniracetam molecule. It is nootropic drug used to ameliorate memory, attention disturbances. Skeletal chemical formula. Paper packaging for drugs. Vector illustration.
Unlike Piracetam (the parent compound), Aniracetam is significantly more potent (approximately 4–5x), fat-soluble (improves brain penetration), and has distinct anxiolytic (anti-anxiety) effects. It is the only racetam with demonstrated positive allosteric modulation of AMPA receptors.
Aniracetam Aniracetam;anixiku
Aniracetam exerts its cognitive-enhancing effects through multiple pathways:
| Pathway | Mechanism | Cognitive Effect |
|---|---|---|
| AMPA receptor positive allosteric modulation | Increases glutamate-induced currents; enhances synaptic plasticity | Memory consolidation, learning, attention |
| Nicotinic acetylcholine receptor (nAChR) modulation | Enhances cholinergic transmission | Focus, working memory |
| 5-HT2A serotonin receptor modulation | Indirect influence (anxiolytic) | Reduced anxiety, improved mood |
| Dopamine D1/D2 receptor modulation | Indirect influence (via cholinergic/glutamatergic) | Motivation, executive function |
| Neuroprotection | Reduces oxidative stress, supports neuronal health | Long-term cognitive maintenance |
insight: Aniracetam’s anxiolytic effect distinguishes it from other racetams. This is attributed to its action on serotonin and dopamine pathways, not just glutamatergic modulation.
Metabolism: Aniracetam is rapidly metabolized in the liver to its primary active metabolite, N-anisoyl-GABA (also known as aniracetam metabolite 1), which contributes to its pharmacological effects. This metabolite has a longer half-life (2–3 hours) than the parent compound (1–2 hours).
LyvBio 주식회사. is a GMP-certified supplier of high-purity Aniracetam for research and development applications.
Supply capabilities:
Assay (HPLC): ≥99.0%
Form: Crystalline powder
Monthly capacity: 50+ kg
Bulk quantities: 10g – 50kg
Lead time: 3–5 days (samples), 10–15 days (bulk)
Documentation: COA, MSDS, HPLC chromatogram, stability data
| Parameter | Specification | Test Method |
|---|---|---|
| Assay (HPLC) | ≥ 99.0% | HPLC-UV (254 nm) |
| 외관 | 흰색에서 미백색의 결정성 분말 | Visual |
| Identification | HPLC retention time, IR (optional) | HPLC / IR |
| Melting Point | 121–124°C | USP <741> |
| 건조 손실 | ≤ 0.5% | USP <731> |
| Residue on Ignition | ≤ 0.1% | USP <281> |
| 중금속 | Pb ≤ 10 ppm; As ≤ 2 ppm; Cd ≤ 1 ppm; Hg ≤ 0.1 ppm | ICP-MS |
| Related Substances | Single impurity ≤ 0.5%; Total ≤ 1.0% | HPLC-UV |
| Residual Solvents | Meet USP <467> | GC |
| Particle Size | 95% through 80 mesh (standard) | Sieve Analysis |
Q: Is Aniracetam the same as Piracetam?
A: No. Aniracetam is a distinct racetam derivative with higher potency (4–5x), lipid solubility (better brain penetration), and unique anxiolytic effects. Piracetam is water-soluble, less potent, and lacks anxiolytic properties.
Q: Is Aniracetam FDA-approved?
A: No. Aniracetam is not FDA-approved for medical use in the United States. It is available as a research chemical for laboratory use only. In some countries (e.g., Russia, certain European nations), it has been used as a prescription medication.
Q: What is the primary metabolite of Aniracetam?
A: N-Anisoyl-GABA (also known as aniracetam metabolite 1). This metabolite contributes to the pharmacological effects and has a longer half-life (2–3 hours) than the parent compound.
Q: Is Aniracetam lipid-soluble?
A: Yes. This is a key advantage over water-soluble racetams (piracetam, oxiracetam), as lipid solubility enhances blood-brain barrier penetration.
Q: Does Aniracetam have anxiolytic effects?
A: Yes. Aniracetam is unique among racetams for its anxiolytic (anti-anxiety) effects, attributed to its influence on serotonin (5-HT2A) and dopamine pathways.
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