Piroxicam

同義語： 4-Hydroxy-2-methyl-N-2-pyridinyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide, CP-16171, Feldene, 36322-90-4

Piroxicam is an oxicam-class nonsteroidal anti-inflammatory drug (NSAID) characterized by a 1,2-benzothiazine-3-carboxamide 1,1-dioxide core bearing a 4-hydroxy substituent and a 2-pyridinylcarboxamide moiety. This structure enables chelation with metal ions and facilitates reversible inhibition of cyclooxygenase (COX) enzymes, which are key to prostaglandin synthesis. Its zwitterionic nature and low aqueous solubility influence formulation strategies, often requiring micronization or salt formation to improve dissolution.

As a long-acting NSAID, piroxicam is used in the management of osteoarthritis, rheumatoid arthritis, and acute musculoskeletal pain. In the pharmaceutical industry, it serves as an active pharmaceutical ingredient (API) in oral capsules, tablets, and topical gels. The compound is also a subject of research in drug delivery and analytical method development, owing to its well-defined pharmacokinetics and stability profile.

Piroxicam is typically manufactured through a multi-step synthesis starting from saccharin or related benzothiazine precursors. Commercial grades meet pharmacopeial standards (USP/EP) and are available as micronized or non-micronized powder. Its therapeutic efficacy and relatively low cost make it a staple in both human and veterinary medicine.

化学構造と性質

Piroxicam exists as a tautomeric mixture, with the enol form predominating in the solid state. The molecule contains a sulfonamide group and a pyridine ring, contributing to its amphoteric character (pKa1 ~2.3, pKa2 ~5.3). It exhibits polymorphism, with the cubic form being most common. The compound is photolabile and should be stored protected from light. Its logP (octanol/water) is approximately 3.06, indicating moderate lipophilicity.

作用機序

• COX-1 and COX-2 inhibition: Piroxicam reversibly inhibits both cyclooxygenase isoforms, reducing the conversion of arachidonic acid to prostaglandin H2, a precursor of pro-inflammatory mediators.
• Neutrophil modulation: It inhibits neutrophil aggregation and chemotaxis, contributing to its anti-inflammatory effects independent of prostaglandin synthesis.
• Cartilage protection: In vitro studies suggest piroxicam may reduce cartilage degradation by inhibiting metalloproteinases.
• Central and peripheral analgesia: By lowering prostaglandin levels in the CNS and peripheral tissues, it alleviates pain and fever.

Quality Specifications (QC Tests)

供給および書類

• 容量: 5 metric tons per month
• リードタイム: 3～5営業日（在庫品）
• ドキュメント: COA, MSDS, TDS available upon request
• パッケージ: 25 kg fiber drum with double polyethylene liner

よくある質問

What is the minimum order quantity (MOQ)?

Our standard MOQ is 1 kg, but we can accommodate smaller quantities for research and development purposes. Please contact us for details.

What is the delivery time?

For stock items, delivery is 3-5 business days from order confirmation.

Do you provide COA and samples?

Yes, we provide a COA for each batch and can send samples for evaluation. Sample dispatch typically takes 1-2 days.

Contact & Ordering Information

• Company: LyvBio Co., Ltd.
• Address: Room 5-0203, Courtyard 205, Lianhu District, Xi’an, Shaanxi, China
• Email: info@lyvbio.com
• Phone: +86-29-65816888

send us your specification for a quotation.