Imatinib

同義語： Imatinib, Gleevec, Glivec, STI-571, CGP 57148B, 4-[(4-methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide

Imatinib is a small-molecule tyrosine kinase inhibitor that changed the treatment paradigm for chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GIST). Developed by Novartis and first approved in 2001, it remains a cornerstone of targeted cancer therapy and a high-demand API for generic manufacturers worldwide. As a phenylaminopyrimidine derivative, imatinib selectively inhibits BCR-ABL, c-KIT, and PDGFR kinases, offering a precise mechanism of action that has made it a benchmark in oncology.

Chemically, imatinib mesylate is the marketed salt form, but the free base is also supplied for research and formulation development. Its structure features a pyrimidine core linked to a benzamide moiety, with a methylpiperazine group enhancing solubility. This design allows for oral bioavailability and metabolic stability, distinguishing it from earlier, less selective kinase inhibitors. The compound is synthesized through a multi-step process involving palladium-catalyzed coupling and amide bond formation, yielding a highly pure active pharmaceutical ingredient (API) that meets stringent pharmacopeial standards.

In the B2B pharmaceutical supply chain, imatinib is primarily used in the production of generic oncology drugs. It is also a key reference standard in analytical laboratories and a starting point for next-generation kinase inhibitor research. LyvBio supplies imatinib API with consistent quality, supported by comprehensive documentation and reliable lead times to meet the demands of formulation companies and research organizations.

Function & Mechanism

• BCR-ABL inhibition: Binds to the ATP-binding site of the BCR-ABL fusion protein, blocking downstream signaling that drives CML cell proliferation.
• c-KIT inhibition: Targets mutant c-KIT receptors in GIST, leading to reduced tumor growth and improved clinical outcomes.
• PDGFR inhibition: Inhibits platelet-derived growth factor receptors, affecting tumor stroma and angiogenesis.
• Selectivity: Sparing many normal kinases, it reduces off-target effects compared to broad-spectrum inhibitors.
• Oral efficacy: Optimized for oral administration, providing sustained plasma levels and patient convenience.

Source & Standardization

• 出典: Synthetic chemical synthesis
• Manufacturing: Multi-step organic synthesis under cGMP conditions
• Standardization: ≥99.0% purity by HPLC; meets EP/USP monographs
• Forms: White to off-white crystalline powder; also available as imatinib mesylate
• 用途: Generic oncology drugs, research, analytical standards

Quality Specifications (QC Tests)

Bulk Supply & Documentation

• 月間処理能力: 500 kg
• リードタイム: 3～5営業日（在庫品）
• ドキュメント: COA, MSDS, TDS, DMF available upon request
• パッケージ: 1 kg, 5 kg, 25 kg drums with double LDPE liners

よくある質問

What is the minimum order quantity (MOQ) for imatinib?

Our standard MOQ is 1 kg. For research purposes, smaller quantities may be available. Please contact us for specific requirements.

What is the delivery time?

For stock items, delivery is 3-5 business days after order confirmation.

Do you provide a Certificate of Analysis (COA) and samples?

Yes, we provide a COA for each batch. Samples are available upon request for qualified customers.

Contact & Ordering Information

• Company: LyvBio Co., Ltd.
• Address: Room 5-0203, Courtyard 205, Lianhu District, Xi’an, Shaanxi, China
• Email: info@lyvbio.com
• Phone: +86-29-65816888

send us your specification for a quotation.