Fisetina

Sinonimi: Fisetin, 3,3′,4′,7-Tetrahydroxyflavone, 5-Deoxyquercetin, 528-48-3, Fisetin powder, Fisetin extract

Fisetin has moved from a niche flavonol to a staple on the radar of supplement formulators and procurement teams who follow the senolytic and NAD+ space. Demand is being pulled by two very different buyer groups: nutraceutical brands building cognitive-aging and healthy-longevity SKUs, and research groups that need a reliable, high-purity standard for in vitro and in vivo work. On the commercial side, it shows up in capsules, powders, and combination formulas alongside resveratrol, quercetin, and pterostilbene, where it is usually the most expensive input and therefore the one that gets the most scrutiny.

What buyers actually care about is the purity profile and the documentation behind it. Fisetin is prone to oxidation and can pick up colored degradation products if it is stored or dried carelessly, so a clean HPLC chromatogram and a low loss on drying are more meaningful than a headline assay number. LyvBio supplies fisetin as a yellow to yellow-green crystalline powder, typically ≥98.0% by HPLC, with heavy metals controlled at ≤10 ppm and residual solvents tested against ICH Q3C limits. Every lot is released with a full COA, and we can provide MSDS, TDS, and where required, a statement on the extraction or synthetic origin. If your specification calls for a tighter assay window or a specific particle size, that can be discussed at the quotation stage rather than treated as a fixed catalogue item.

Product Overview & Composition

Fisetin is a single, well-defined flavonol rather than a botanical extract with a variable marker profile. That distinction matters for formulators: you are buying a discrete molecule with a fixed molecular weight and a sharp melting point, not a spectrum of glycosides and aglycones whose ratio depends on the harvest. The material is practically a pure aglycone, which is why it dissolves readily in ethanol, DMSO, and acetone but only sparingly in water—a point worth planning for early if you are developing a beverage or a water-based stick pack.

In the solid state it is a crystalline powder with a characteristic yellow color that intensifies with particle size reduction. It is stable under normal warehouse conditions when kept dry and protected from light, but it will discolor if exposed to moisture and air over long periods. For most nutraceutical and research applications, the standard grade is ≥98% by HPLC with the main impurities being structurally related flavonoids such as quercetin and kaempferol at trace levels.

Key Applications

• Senolytic and longevity formulations: Fisetin is one of the most studied senolytic flavonoids and is used in capsules and powders positioned around healthy aging and cellular health.
• Cognitive support products: It appears in nootropic and memory-support blends, often combined with other polyphenols, where it is included for its antioxidant and neuroprotective profile.
• Antioxidant and anti-inflammatory supplements: The flavonol scaffold gives it broad radical-scavenging activity, making it a natural fit for general wellness and joint-health SKUs.
• Research and reference standards: Laboratories use high-purity fisetin as an analytical standard and as a tool compound in studies on sirtuins, mTOR, and senescence pathways.
• Cosmetic and topical actives: Its antioxidant and tyrosinase-related activity has attracted interest in skin-care formulations, particularly anti-aging and brightening products.
• Functional food and beverage concepts: Although solubility is a challenge, fisetin is being evaluated in dry-mix and emulsified formats for premium functional foods.

Quality & Standards

Packaging & Supply

• Confezionamento: 1 kg and 5 kg double PE-lined aluminium foil bags inside fibre drums; 25 kg fibre drums for bulk orders. Custom packaging available on request.
• MOQ: 1 kg for standard grade; 25 kg for contract pricing.
• Tempi di consegna: 3-5 business days (stock items)
• Documentazione: COA, MSDS, TDS, and origin statement supplied with every shipment. Additional documents such as residual solvent declaration, heavy metal testing, and microbial reports are available on request.

Richiesta di preventivo

• LyvBio S.r.l. — E-mail: info@lyvbio.com