Citicoline (CDP-Choline)

Sinonimi: Citicoline, CDP-Choline, Cytidine 5′-diphosphocholine, Cytidine diphosphate choline, Cidilin, Somazina, Recognan

Citicoline, also known as CDP-choline, is a naturally occurring nucleotide derivative that serves as a critical intermediate in the biosynthesis of phosphatidylcholine, the major phospholipid of cell membranes. Its structure comprises a cytidine moiety linked to a choline group via a diphosphate bridge, a configuration that allows it to participate directly in phospholipid metabolism and to donate choline and cytidine for downstream anabolic pathways. This dual donor role distinguishes citicoline from simple choline salts and underlies its broad pharmacological profile.

First isolated in the 1950s and later developed as a therapeutic agent, citicoline has been the subject of extensive clinical research, particularly in neurology and ophthalmology. It is available in various grades, including pharmaceutical grade (for injectable and oral formulations) and food grade (for dietary supplements). The product is typically supplied as the sodium salt, which is more stable and water-soluble than the free acid form. Our citicoline is manufactured under cGMP conditions and is standardized to ≥98.0% purity by HPLC, ensuring consistent quality for formulation and research applications.

In the B2B space, citicoline is primarily used as an active pharmaceutical ingredient (API) in finished dosage forms, as a nutraceutical ingredient in brain health supplements, and as a research chemical in studies investigating neuroprotection, membrane repair, and mitochondrial function. Its well-documented safety profile and favorable pharmacokinetics make it a preferred choice for formulators targeting cognitive support and neuroregeneration.

Chemical Structure & Properties

Citicoline is a polar, water-soluble molecule with a molecular weight of 488.32 g/mol (free acid). The diphosphate linkage is susceptible to hydrolysis, particularly under acidic or high-temperature conditions, which is why the sodium salt form is commonly used to enhance stability. The molecule is highly hygroscopic and should be stored in tightly sealed containers away from moisture. Its UV absorption maximum is around 280 nm due to the cytosine ring, a property often utilized in analytical quantification. The presence of both phosphate and amino groups gives citicoline a zwitterionic character, influencing its solubility and interaction with biological membranes.

Meccanismo d'azione

• Phosphatidylcholine synthesis: Citicoline provides both cytidine and choline moieties for the Kennedy pathway, promoting the regeneration of neuronal membranes and synaptic structures.
• Acetylcholine precursor: By liberating choline, citicoline supports acetylcholine synthesis, which is crucial for memory and cognitive function.
• Mitochondrial support: Citicoline stabilizes cardiolipin and preserves mitochondrial membrane integrity, reducing oxidative stress and apoptosis in ischemic conditions.
• Neurotransmitter modulation: It enhances dopaminergic and noradrenergic transmission by increasing tyrosine hydroxylase activity and dopamine receptor density in certain brain regions.
• Anti-inflammatory effects: Citicoline downregulates pro-inflammatory cytokines and reduces microglial activation, contributing to neuroprotection.

Quality Specifications

Supply & Documentation

• Capacity: 5 metric tons per month
• Tempi di consegna: 3-5 business days (stock items)
• Documentazione: COA, MSDS, TDS, GMP certificate, DMF available upon request
• Confezionamento: 25 kg fiber drum with double polyethylene liner, or as per customer requirements

Richiesta di preventivo

• LyvBio S.r.l. — E-mail: info@lyvbio.com