Calcium D-Pantothenate

Synonyms: D-Pantothenic acid calcium salt, Vitamin B5 calcium salt, Calcium pantothenate, (R)-(+)-N-(2,4-Dihydroxy-3,3-dimethylbutyryl)-β-alanine calcium salt

Calcium D-pantothenate is the calcium salt of D-pantothenic acid, the biologically active form of vitamin B5. It is a white, crystalline, water-soluble powder that is stable under normal storage conditions and is the preferred commercial form of pantothenic acid due to its superior stability compared to the free acid or sodium salt. As a precursor to coenzyme A (CoA), it plays a fundamental role in cellular metabolism, particularly in fatty acid synthesis and energy production.

Most of the world’s calcium D-pantothenate is produced synthetically, though it is also found naturally in nearly all living cells. The synthesis typically involves the reaction of D-pantolactone with β-alanine, followed by neutralization with calcium hydroxide. The resulting product is a racemic mixture? No, the D-form is the only biologically active isomer, and commercial production is stereospecific to yield the D-enantiomer.

Calcium D-pantothenate is commercially available in high purity grades, typically 98% or higher, making it suitable for pharmaceutical, nutraceutical, and food fortification applications. Its excellent water solubility and compatibility with other vitamins make it a staple in multivitamin formulations, sports nutrition products, and animal feed supplements.

Product Overview & Composition

Calcium D-pantothenate is a calcium salt of the vitamin B5 vitamer, D-pantothenic acid. It consists of two molecules of D-pantothenic acid bound to one calcium ion, resulting in a molecular weight of 476.53 g/mol. The compound is freely soluble in water, slightly soluble in ethanol, and practically insoluble in ether. It is stable in air but hygroscopic under high humidity conditions. The calcium salt form is preferred over the free acid because it is more stable and less acidic, making it easier to handle and formulate.

In terms of chemical structure, calcium D-pantothenate is the calcium salt of (R)-N-(2,4-dihydroxy-3,3-dimethylbutyryl)-β-alanine. The molecule contains a chiral center, and only the D-isomer is biologically active. The calcium ion is essential for the salt formation and contributes to the compound’s stability. The product is typically manufactured to meet pharmacopeial standards such as USP, EP, and BP, ensuring consistent quality for pharmaceutical and food applications.

Key Applications

• Pharmaceuticals: Used in multivitamin tablets, capsules, and injectables as a source of vitamin B5. It is often combined with other B-complex vitamins.
• Nutraceuticals: Incorporated into dietary supplements for energy metabolism, skin health, and hair care.
• Food Fortification: Added to breakfast cereals, beverages, and infant formula to enhance nutritional value.
• Animal Feed: Supplemented in poultry, swine, and aquaculture feed to prevent pantothenic acid deficiency and promote growth.
• Cosmetics: Used in skincare products for its moisturizing and soothing properties.

Quality & Standards

Packaging & Supply

• Confezionamento: 25 kg fiber drum with double polyethylene liner, or as per customer requirements.
• MOQ: 25 kg.
• Tempi di consegna: 3-5 business days (stock items)
• Documentazione: COA, MSDS, TDS available upon request.

Richiesta di preventivo

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