Ahk-cu

Sinonimi: Copper tripeptide-3, AHK-Cu, Alanine-Histidine-Lysine copper complex, Copper peptide AHK

Ahk-cu is a synthetic copper-binding tripeptide with the sequence Alanine-Histidine-Lysine. The histidine residue provides a strong imidazole nitrogen donor, allowing the peptide to chelate copper(II) in a stable square-planar geometry. This copper-peptide complex is structurally distinct from the more common GHK-Cu, offering a different spatial arrangement of the amino acid side chains that influences its interaction with cellular targets.

Originally developed for wound healing research, Ahk-cu has gained attention in cosmetic and pharmaceutical formulations for its ability to deliver copper ions to skin and hair follicle cells. The peptide acts as a carrier, facilitating copper uptake and modulating extracellular matrix remodeling. It is typically produced via solid-phase peptide synthesis and supplied as a high-purity powder for topical and research applications.

In the B2B space, Ahk-cu is valued for its stability and compatibility with a range of delivery systems, from serums to creams. Formulators incorporate it into anti-aging and hair care products, where it supports collagen synthesis and antioxidant defense. Its well-defined mechanism and consistent quality make it a reliable active for companies targeting dermatological and regenerative markets.

Chemical Structure & Properties

Ahk-cu features a tripeptide backbone with alanine, histidine, and lysine residues. The copper ion is coordinated by the imidazole nitrogen of histidine, the alpha-amino group of alanine, and the amide nitrogen of the peptide bond, forming a stable complex. The lysine side chain remains free, contributing to water solubility and allowing further functionalization if needed. The compound is stable under neutral pH but may dissociate in strongly acidic conditions.

Meccanismo d'azione

• Copper delivery: The peptide binds copper(II) and facilitates its transport into cells, where copper acts as a cofactor for enzymes like lysyl oxidase and superoxide dismutase.
• Collagen stimulation: By delivering copper, Ahk-cu upregulates collagen and elastin synthesis, supporting skin firmness and elasticity.
• Antioxidant defense: Copper is essential for SOD activity, helping to neutralize free radicals and reduce oxidative stress.
• Hair follicle support: Studies suggest that Ahk-cu promotes dermal papilla cell proliferation, potentially extending the anagen phase of hair growth.

Quality Specifications (QC Tests)

Supply & Documentation

• Capacity: 50 kg per month
• Tempi di consegna: 3-5 business days (stock items)
• Documentazione: COA, MSDS, TDS available upon request
• Confezionamento: 1 kg, 5 kg, 10 kg double PE bags in fiber drums

Frequently Asked Questions

What is the MOQ for Ahk-cu?

Our minimum order quantity is 1 kg. For larger quantities, please contact us for pricing and availability.

What is the delivery time?

For stock items, delivery is 3-5 business days after order confirmation.

Do you provide a COA and samples?

Yes, we provide a COA for each batch. Samples are available upon request; sample preparation and dispatch take 1-2 days.

Contact & Ordering Information

• Company: LyvBio Co., Ltd.
• Address: Room 5-0203, Courtyard 205, Lianhu District, Xi’an, Shaanxi, China
• Email: info@lyvbio.com
• Phone: +86-29-65816888

send us your specification for a quotation.