Tripeptide-29

Synonyme: Glycyl-L-histidyl-L-lysine, GHK, Copper Tripeptide-1, Gly-His-Lys, Tripeptide-29

Tripeptide-29, also known as glycyl-L-histidyl-L-lysine (GHK), is a naturally occurring tripeptide with the sequence glycine-histidine-lysine. This short peptide is renowned for its high affinity for copper(II) ions, forming a stable complex that plays a pivotal role in wound healing, tissue regeneration, and collagen synthesis. The presence of the histidine residue provides a copper-binding site, while the lysine contributes to the peptide’s overall charge and interaction with cell membranes.

First isolated from human plasma in 1973 by Loren Pickart, GHK is found in various tissues and body fluids, including saliva, urine, and plasma. Its concentration in plasma is approximately 200 ng/mL in young adults, but this level declines with age. Due to its potent biological activities, GHK and its copper complex (Copper Tripeptide-1) have become key ingredients in cosmeceuticals and wound care products. The peptide is typically produced via solid-phase peptide synthesis and is available in high purity for research and industrial applications.

In the B2B pharmaceutical and cosmetic raw materials sector, Tripeptide-29 is valued for its ability to promote collagen and glycosaminoglycan synthesis, stimulate angiogenesis, and exhibit antioxidant and anti-inflammatory effects. It is widely used in anti-aging skincare formulations, wound dressings, and tissue engineering scaffolds. Its safety profile and efficacy have been supported by numerous in vitro and in vivo studies, making it a versatile active for advanced dermal care.

Chemical Structure & Properties

Tripeptide-29 is a linear tripeptide with the sequence Gly-His-Lys. Its molecular formula is C14H25N5O5, and it has a molecular weight of 343.38 g/mol. The peptide is highly soluble in water and polar organic solvents, and it appears as a white to off-white powder. The imidazole group of histidine enables chelation of metal ions, particularly copper, forming a blue complex. This property is central to its biological activity. The peptide is stable under recommended storage conditions, but it should be protected from moisture and light to prevent degradation.

Mechanism of Action

• Copper chelation and delivery: GHK binds copper(II) with high affinity, facilitating its transport into cells and modulating copper-dependent enzymes.
• Collagen synthesis: Upregulates collagen types I, III, and IV, as well as elastin, by stimulating fibroblasts.
• Antioxidant and anti-inflammatory: Scavenges free radicals and reduces inflammatory cytokines, protecting cells from oxidative stress.
• Angiogenesis: Promotes the formation of new blood vessels, enhancing nutrient delivery and wound healing.
• Extracellular matrix remodeling: Stimulates the production of glycosaminoglycans and proteoglycans, improving skin firmness and elasticity.

Quality Specifications

Supply & Documentation

• Capacity: 500 kg per month
• Lieferzeit: 3–5 Werktage (Lagerware)
• Dokumentation: COA, MSDS, TDS, and additional technical support available upon request
• Verpackung: 1 kg, 5 kg, 10 kg in aluminum foil bags or fiber drums, customizable packaging options

Angebotsanfrage

• LyvBio GmbH. — E-Mail: info@lyvbio.com