Thiamidol

Synonyme: Thiamidol, Isobutylamido Thiazolyl Resorcinol, 4-(4-Hydroxyphenyl)-2-(4-hydroxyphenyl)thiazole-5-carboxamide, ITR, Thiamidol 1428450-95-6

Thiamidol is a synthetic resorcinol derivative that has rapidly become a benchmark in topical hyperpigmentation research. First developed by Beiersdorf, it was designed to address the limitations of existing tyrosinase inhibitors by targeting human tyrosinase with exceptional selectivity. Unlike many plant-derived actives, Thiamidol is a single, well-defined molecule, offering consistent potency and predictable behavior in formulation.

Its chemical structure features a thiazole core substituted with two hydroxyphenyl groups and a carboxamide side chain. This unique arrangement allows it to bind the active site of human tyrosinase more effectively than arbutin or kojic acid, making it one of the most potent inhibitors available for cosmetic and dermatological applications.

In the personal care industry, Thiamidol is primarily used in skin-brightening serums, creams, and lotions aimed at reducing age spots, melasma, and post-inflammatory hyperpigmentation. It is also a valuable tool in dermatological research for studying melanogenesis and pigmentation disorders.

Function & Mechanism

• Tyrosinase inhibition: Competitively inhibits human tyrosinase, the key enzyme in melanin production, with high specificity.
• Melanin synthesis reduction: Decreases melanin formation in melanocytes, leading to visible skin tone evening.
• Antioxidant activity: Scavenges free radicals that contribute to oxidative stress and pigmentation.
• Anti-inflammatory support: May reduce inflammation associated with hyperpigmentation.
• Long-lasting effect: Provides sustained depigmenting action with regular use.

Source & Standardization

• Quelle: Synthetic chemical synthesis
• Extraction: Not applicable (synthetic route)
• Standardization: ≥98.0% (HPLC)
• Forms: White to off-white crystalline powder
• Anwendungen: Skin care products, dermatological research, cosmetic formulations

Quality Specifications (QC Tests)

Bulk Supply & Documentation

• Monthly capacity: 500 kg
• Lieferzeit: 3–5 Werktage (Lagerware)
• Dokumentation: COA, MSDS, TDS available upon request
• Verpackung: 1 kg, 5 kg, 25 kg drums

Häufig gestellte Fragen

What is the minimum order quantity (MOQ)?

Our MOQ for Thiamidol is 1 kg, but we can accommodate smaller quantities for research and development purposes. Please contact us for details.

What is the delivery time?

We keep stock of Thiamidol, so orders are typically shipped within 3-5 business days after order confirmation.

Do you provide COA and samples?

Yes, we provide a COA for each batch. Samples are available upon request; sample delivery usually takes 1-2 days.

Contact & Ordering Information

• Company: LyvBio Co., Ltd.
• Address: Room 5-0203, Courtyard 205, Lianhu District, Xi’an, Shaanxi, China
• Email: info@lyvbio.com
• Phone: +86-29-65816888

send us your specification for a quotation.