Dihexa

Synonyme: N-hexanoic-Tyr-Ile-(6) aminohexanoic amide; PNB-0408; DIHEXA

Dihexa is a synthetic hexapeptide analog derived from angiotensin IV, engineered to cross the blood-brain barrier and activate the hepatocyte growth factor (HGF)/c-Met signaling pathway. Its structure incorporates non-natural amino acids, including a hexanoic acid moiety and a 6-aminohexanoic acid linker, which confer metabolic stability and enhanced lipophilicity compared to the native peptide. This design allows Dihexa to function as a potent neurotrophic agent, promoting synaptic connectivity and dendritic spine formation in preclinical models.

As a research chemical, Dihexa is supplied as a high-purity powder (≥98% by HPLC) and is intended for laboratory investigations into cognitive enhancement, neuroprotection, and synaptic plasticity. Its unique mechanism of action distinguishes it from traditional nootropics, offering a targeted approach to modulating neurotrophic factors. While not approved for human use, Dihexa has garnered significant interest in the scientific community for its potential applications in neurodegenerative disorders and cognitive decline.

Our Dihexa is synthesized under strict quality control protocols, ensuring consistent purity and batch-to-batch reproducibility. Each lot is accompanied by a comprehensive Certificate of Analysis (COA), and we offer custom packaging to meet specific research requirements. With a focus on reliability and technical support, we cater to pharmaceutical and biotechnology companies seeking a dependable source for this advanced peptide.

Chemical Structure & Properties

Dihexa’s molecular formula is C₃₇H₅₅N₅O₅, with a molecular weight of 673.87 g/mol. The peptide backbone consists of tyrosine, isoleucine, and a 6-aminohexanoic acid residue, further modified with a hexanoic acid chain at the N-terminus. This structural composition enhances its lipophilicity, facilitating passive diffusion across biological membranes. Dihexa is soluble in organic solvents such as DMSO and ethanol, and sparingly soluble in aqueous buffers, necessitating careful formulation for in vitro studies. The compound is stable when stored desiccated at -20°C, but prolonged exposure to light or moisture can lead to degradation.

Mechanism of Action

• HGF/c-Met activation: Dihexa binds to and activates the c-Met receptor, mimicking the action of HGF, which leads to downstream phosphorylation and neurotrophic signaling.
• Synaptogenesis: Activation of c-Met promotes the formation of new synapses and dendritic spines, enhancing synaptic plasticity and cognitive function.
• Neuroprotektion: Dihexa has been shown to protect neurons from oxidative stress and apoptosis in various preclinical models.
• Long-term potentiation (LTP): It facilitates LTP, a cellular correlate of learning and memory, in hippocampal slices.

Quality Specifications

Supply & Documentation

• Capacity: Monthly production capacity of 10 kg, scalable upon request.
• Lieferzeit: 3–5 Werktage (Lagerware)
• Dokumentation: COA, MSDS, TDS available upon request.
• Verpackung: 1 g, 5 g, 10 g in amber glass vials, or customized packaging under inert atmosphere.

Angebotsanfrage

• LyvBio GmbH. — E-Mail: info@lyvbio.com