Cetilistat

Cetilistat (CAS 282526-98-1) is a novel lipase inhibitor designed for the management of obesity. Unlike orlistat, which is a saturated derivative, cetilistat features a benzoxazinone core that offers improved gastrointestinal tolerability. It works by irreversibly inhibiting pancreatic and gastric lipases, thereby reducing dietary fat absorption by approximately 30% at therapeutic doses. We supply this API in high purity (≥99% by HPLC) as a white to off-white crystalline powder, suitable for oral solid dosage forms and clinical research.

As a second-generation lipase inhibitor, cetilistat has undergone Phase III trials for obesity and type 2 diabetes, showing comparable efficacy to orlistat with fewer steatorrhea side effects. Its chemical name is 2-(2,4-difluorophenyl)-6-(2-{2-[2-(2,2-dimethylpropyl)phenoxy]ethoxy}ethyl)-4,5-dihydro-1,3-oxazin-4-one, and it is also known by the code ATL-962. This product is intended for pharmaceutical formulation development and research purposes only.

Synonyme: 2-(2,4-Difluorophenyl)-6-(2-{2-[2-(2,2-dimethylpropyl)phenoxy]ethoxy}ethyl)-4,5-dihydro-1,3-oxazin-4-one, ATL-962, Cetilistat (USAN), 2H-1,3-Oxazin-4-one, 2-(2,4-difluorophenyl)-6-(2-(2-(2-(2,2-dimethylpropyl)phenoxy)ethoxy)ethyl)-4,5-dihydro-

Anwendungen

• Anti-obesity drug formulations (oral capsules and tablets)
• Adjunct therapy for type 2 diabetes management
• Lipase inhibition studies in metabolic research
• Clinical trial material and reference standard

Qualität und Dokumentation

Every batch is tested for assay (HPLC ≥99%), loss on drying (≤0.5%), and heavy metals (≤10 ppm). Full COA, MSDS, and TDS are provided with each shipment. Stability data under ICH conditions is available upon request to support your formulation development and regulatory filings.

Verpackung und Beschaffung

Standard packaging: 100 g, 500 g, and 1 kg. Custom packing sizes are available. In-stock items ship within 3-5 business days; MOQ is 100 g. For pricing, samples, or bulk orders, contact our sales team.

Angebotsanfrage

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