Calcium Alpha ketoglutarate

Synonyme: Calcium 2-oxoglutarate, Calcium α-ketoglutarate, Ca-AKG, Calcium 2-oxopentanedioate, 2-Ketoglutaric acid calcium salt, Calcium oxoglurate

Calcium Alpha ketoglutarate (Ca-AKG) is the calcium salt of α-ketoglutaric acid, a key intermediate in the citric acid cycle and a central node in cellular nitrogen and carbon metabolism. Unlike the free acid, which is highly hygroscopic and unstable, the calcium salt offers a stable, water-soluble crystalline solid that is straightforward to handle in solid dosage forms and liquid formulations. It has become a staple in the nutraceutical and pharmaceutical ingredient toolkit, particularly for products targeting healthy aging, muscle performance, and metabolic support.

The compound sits at the intersection of energy metabolism and epigenetic regulation. α-Ketoglutarate serves as a co-substrate for dioxygenases that demethylate DNA and histones, and it also acts as a nitrogen shuttle in the urea cycle and in transamination reactions. Because of this dual role, Ca-AKG is investigated not only as a sports nutrition ingredient but also as a research chemical in longevity and metabolic studies. Its calcium counterion adds a nutritional bonus—delivering a highly bioavailable form of calcium without the alkalinity of carbonate or the gastrointestinal load of some other salts.

From a sourcing perspective, Calcium Alpha ketoglutarate is produced via controlled neutralization of high-purity α-ketoglutaric acid with a calcium base, followed by crystallization and drying. The resulting material is typically a white to off-white powder with an assay of 98% or higher by HPLC. It is non-hygroscopic under normal storage conditions, which gives formulators a practical advantage when developing tablets, capsules, or stick packs. The ingredient is generally recognized for its clean taste profile, making it compatible with ready-to-mix beverages and functional foods where organoleptic quality matters.

In the B2B supply chain, Ca-AKG is offered in several hydrate forms and particle sizes to suit different manufacturing processes. Buyers should specify the desired hydrate form and particle size distribution, as these parameters influence flowability, compressibility, and dissolution rate. The calcium content can also be a specification point for customers who want to standardize their finished product’s mineral contribution. With a growing body of literature on α-ketoglutarate’s role in metabolic and age-related pathways, demand for the calcium salt continues to rise among supplement brands and contract manufacturers.

Funktion

• Metabolic intermediate: Supplies a key citric acid cycle intermediate, supporting cellular energy production and nitrogen balance.
• Epigenetic co-substrate: Acts as a cofactor for dioxygenases involved in DNA and histone demethylation, influencing gene expression.
• Muscle performance support: May help reduce ammonia accumulation and improve exercise recovery when used in sports nutrition formulations.
• Calcium delivery: Provides a bioavailable source of calcium with good tolerability for bone and general health applications.
• Antioxidant-related pathways: Supports glutathione metabolism and cellular redox balance through its role in amino acid metabolism.
• Longevity research: Commonly studied in aging and healthspan models as a modulator of metabolic and epigenetic markers.

Source & Standardization

• Quelle: Synthetic, derived from high-purity α-ketoglutaric acid and a calcium base.
• Production: Neutralization, crystallization, filtration, and drying under controlled conditions.
• Standardization: ≥98.0% calcium alpha-ketoglutarate by HPLC; calcium content typically 20.0–24.0%.
• Forms: White to off-white crystalline powder; available in various hydrate forms and particle sizes.
• Anwendungen: Dietary supplements, sports nutrition, functional foods, pharmaceutical research, cell culture media.

Technische Daten

Documentation & Supply

• Monthly capacity: 5 metric tons
• Lieferzeit: 3–5 Werktage (Lagerware)
• Dokumentation: COA, MSDS, TDS, nutritional analysis, and regulatory support available upon request
• Verpackung: 25 kg fiber drums with double polyethylene liners; custom packaging options for small quantities
• Lagerung: Store in a cool, dry place away from direct sunlight; retest period 24 months from date of manufacture

Angebotsanfrage

• LyvBio GmbH. — E-Mail: info@lyvbio.com