N-Methyl-DL-Aspartic Acid (NMA)

Synonyms: N-Methyl-DL-aspartic acid, NMA, 2-(Methylamino)succinic acid, DL-N-Methylaspartic acid, N-Methylaspartate, NMDA (non-specific)

In the evolving landscape of neuroprotective and cognitive health ingredients, N-Methyl-DL-Aspartic Acid (NMA) has carved out a distinct niche. Unlike its controversial receptor-agonist cousin NMDA, NMA is a versatile building block that has captured the attention of formulators and researchers alike. Its unique profile makes it a valuable component in products targeting glutamate modulation, cognitive resilience, and even specialized sports nutrition. As the demand for nootropics and neuroprotective agents continues to surge, NMA stands out as a compound with untapped potential for innovative product development.

NMA is a methylated derivative of aspartic acid, an endogenous amino acid. It exists as a racemic mixture of D and L enantiomers. The compound is structurally related to the excitatory neurotransmitter glutamate and has been studied for its ability to interact with the glutamatergic system. While it shares some structural similarities with NMDA, NMA exhibits a distinct pharmacological profile, acting as a partial agonist at NMDA receptors and influencing other pathways. This nuanced activity positions NMA as a candidate for modulating synaptic plasticity and neuronal health without the excitotoxicity concerns associated with high-potency NMDA receptor agonists.

Our N-Methyl-DL-Aspartic Acid is produced under stringent conditions to ensure high purity and consistent quality. Each batch is assayed by HPLC to guarantee a minimum purity of 98.0%, making it suitable for a wide range of applications from research to finished dietary supplements. The white crystalline powder is water-soluble, facilitating easy incorporation into various dosage forms. With a focus on reliability and regulatory compliance, LyvBio supplies NMA with complete documentation, ensuring seamless integration into your supply chain.

Product Overview & Composition

N-Methyl-DL-Aspartic Acid is a synthetic compound that mimics the structure of naturally occurring amino acids. It is manufactured through a controlled methylation process of DL-aspartic acid, yielding a racemic mixture. The molecule features a methyl group attached to the nitrogen atom, which influences its interaction with biological targets. This modification enhances its lipophilicity slightly compared to aspartic acid, potentially affecting its bioavailability and distribution.

In terms of composition, NMA is a single chemical entity, not a mixture of enantiomers with different activities. The racemic nature means it contains equal amounts of D and L forms, which can be advantageous in research settings where both enantiomers might contribute to the observed effects. Our production process ensures that the ratio remains consistent, providing researchers and formulators with a reliable material for their studies.

Key Applications

• Cognitive Health Supplements: NMA is incorporated into nootropic formulations aimed at supporting memory, focus, and overall brain health, leveraging its role in glutamatergic signaling.
• Neuroprotective Research: Studied for its potential to protect neurons from excitotoxic damage and modulate NMDA receptor activity, making it a subject of interest in neurodegenerative disease research.
• Sports Nutrition: As a derivative of aspartic acid, NMA is explored for its potential to enhance athletic performance and recovery by influencing energy metabolism and neurotransmitter balance.
• Pharmaceutical Intermediates: Used as a building block in the synthesis of more complex pharmaceutical compounds, particularly those targeting neurological pathways.
• Research Reagents: Employed in biochemical and pharmacological studies to investigate the role of NMDA receptors and glutamate transporters.

Quality & Standards

Packaging & Supply

• Packaging: 25 kg net weight in fiber drums with double polyethylene inner bags. Custom packaging available upon request.
• MOQ: 1 kg for initial orders, with scale-up options for commercial quantities.
• Lead time: 3-5 business days (stock items)
• Documentation: Certificate of Analysis (COA), Material Safety Data Sheet (MSDS), Technical Data Sheet (TDS), and other regulatory documents as needed.

Request For Quote

• LyvBio Co., Ltd. — Email: info@lyvbio.com