Spermidine Trihydrochloride

Synonyms: Spermidine trihydrochloride, N-(3-Aminopropyl)-1,4-butanediamine trihydrochloride, 1,5,10-Triazadecane trihydrochloride, Spermidine hydrochloride, 4-Azaoctamethylenediamine trihydrochloride

Spermidine trihydrochloride is the trihydrochloride salt of spermidine, a naturally occurring polyamine found in all living organisms. It plays a critical role in cellular processes such as DNA stabilization, RNA transcription, and protein synthesis. First isolated from semen in 1678 by Antonie van Leeuwenhoek, spermidine has since been recognized as a key regulator of autophagy and longevity pathways.

As a polycation at physiological pH, spermidine binds to nucleic acids and phospholipids, influencing chromatin structure and membrane integrity. Its trihydrochloride form offers superior stability and water solubility compared to the free base, making it ideal for biochemical assays and cell culture applications. The compound is a white crystalline powder, highly soluble in water, and stable under recommended storage conditions.

In the pharmaceutical and nutraceutical industries, spermidine trihydrochloride is standardized to ≥98% purity (HPLC) and is widely used in anti-aging supplements, autophagy research, and as a reference standard. Its ability to induce autophagy has sparked interest in neurodegenerative disease and cardioprotection studies, driving demand for high-quality material.

Function

• Autophagy induction: Activates autophagy via mTOR-independent pathways, promoting cellular recycling.
• Anti-aging support: Extends lifespan in model organisms by enhancing stress resistance.
• Cardioprotection: Reduces cardiac hypertrophy and improves diastolic function in preclinical models.
• Neuroprotection: Mitigates neuronal death by clearing aggregated proteins.
• Nucleic acid stabilization: Binds DNA and RNA, influencing gene expression and translation.

Source & Standardization

• Source: Synthetic, derived from putrescine and decarboxylated S-adenosylmethionine.
• Extraction: Chemical synthesis followed by crystallization and purification.
• Standardization: ≥98.0% spermidine trihydrochloride (HPLC).
• Forms: White to off-white crystalline powder.
• Applications: Dietary supplements, cell culture, autophagy research, pharmaceutical intermediates.

Specifications

Documentation & Supply

• Monthly capacity: 500 kg
• Lead time: 3-5 business days (stock items)
• Documentation: COA, MSDS, TDS, HPLC chromatogram
• Packaging: 1 kg aluminum foil bag, 5 kg fiber drum, 25 kg fiber drum with double PE liners

Request For Quote

• LyvBio Co., Ltd. — Email: info@lyvbio.com