Resveratrol

Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a naturally occurring polyphenolic phytoalexin produced by various plant species in response to environmental stress, include fungal infection, UV irradiation, and mechanical injury. It is found in a variety of dietary sources, most notably in the skins of red grapes, red wine, berries, and the roots of Polygonum cuspidatum (Japanese knotweed，Polygonum cuspidatum，giant knot weed), which serves as the primary commercial source.

Resveratrol exists as two geometric isomers: trans-resveratrol and cis-resveratrol, with the trans form being the predominant biologically active isomer and the primary constituent of standardized extracts. The compound has been extensively studied for its ability to activate sirtuin 1 (SIRT1), a NAD⁺-dependent deacetylase involved in cellular stress resistance, mitochondrial biogenesis, and metabolic regulation.

Reynoutria japonica Houtt

Source & Isomerism

• Primary Source: Polygonum cuspidatum (Japanese knotweed) root extract

• Isomeric Composition: ≥98% trans-resveratrol (all-trans isomer)

• cis-Resveratrol: May be present as minor component (≤2%)

Spec