Acetyl Tetrapeptide-5

Synonyms: Acetyl Tetrapeptide-5, Acetyl Glutamyl-Methionyl-Glutaminyl-Arginine, Acetyl-EEMQRR, AHP-1, Acetyl Tetrapeptide-5 (Cosmetic Peptide)

Acetyl Tetrapeptide-5 is a synthetic tetrapeptide consisting of four amino acids—glutamic acid, methionine, glutamine, and arginine—with an acetyl group capping the N-terminus. This modification enhances stability and skin penetration, distinguishing it from unmodified peptides. Initially developed for cosmetic applications, it has gained traction in pharmaceutical research for its role in modulating cellular stress and inflammatory pathways.

Structurally, Acetyl Tetrapeptide-5 mimics a fragment of the human protein decorin, which regulates collagen fibrillogenesis and cell signaling. Its sequence, Ac-Glu-Met-Gln-Arg-NH2, is designed to interact with specific receptors involved in fibroblast activity and extracellular matrix remodeling. This peptide is often compared to other acetylated peptides like Acetyl Hexapeptide-8, but its unique sequence targets different biological processes, making it a versatile tool in both cosmetic and therapeutic formulations.

Our Acetyl Tetrapeptide-5 is manufactured via solid-phase peptide synthesis and purified using preparative HPLC to achieve a purity of ≥98%. It is available in research-grade and cGMP-compliant grades, suitable for a wide range of applications including anti-aging skincare, wound healing studies, and inflammation research. The product is supplied as a lyophilized powder to ensure long-term stability, with custom packaging options to meet diverse R&D and production needs.

Function

• Anti-inflammatory activity: Reduces pro-inflammatory cytokine production in skin cells.
• Collagen synthesis promotion: Stimulates fibroblast proliferation and collagen I & III synthesis.
• Antioxidant defense: Scavenges free radicals and protects against oxidative stress.
• Skin barrier repair: Enhances keratinocyte differentiation and lipid barrier formation.
• Wound healing support: Accelerates tissue regeneration in in vitro models.

Source & Standardization

• Source: Synthetic peptide produced by solid-phase peptide synthesis (SPPS).
• Extraction: Not applicable; chemically synthesized.
• Standardization: ≥98.0% purity by HPLC; identity confirmed by mass spectrometry.
• Forms: Lyophilized powder, sterile-filtered aqueous solution (custom).
• Applications: Cosmetic formulations (anti-aging, moisturizing), pharmaceutical research, cell culture studies.

Specifications

Documentation & Supply

• Monthly capacity: 50 kg
• Lead time: 3-5 business days (stock items)
• Documentation: COA, MSDS, TDS, HPLC, MS, and stability data available upon request
• Packaging: 1 g, 5 g, 10 g in amber glass vials; bulk quantities in polyethylene containers

Request For Quote

• LyvBio Co., Ltd. — Email: info@lyvbio.com