TAK-653

同義語： TAK-653, TAK653, AMPA receptor potentiator, mGluR modulator, TAK-653 free base

In the fast-paced world of central nervous system drug discovery, the demand for highly selective, brain-penetrant compounds has never been greater. TAK-653 has emerged as a standout molecule, capturing the attention of researchers and pharmaceutical companies alike. As a potent and selective AMPA receptor potentiator, it offers a promising avenue for addressing cognitive deficits and neurological disorders, making it a hot commodity in both academic and industrial R&D pipelines.

TAK-653 is a synthetic small molecule developed by Takeda Pharmaceutical Company. It belongs to the class of ampakines, which are positive allosteric modulators of the AMPA receptor. Unlike traditional AMPA receptor agonists, TAK-653 does not cause receptor desensitization and exhibits excellent selectivity over other glutamate receptors. This profile makes it an invaluable tool for studying synaptic plasticity, learning, and memory.

Manufactured under strict quality control, TAK-653 is typically available at high purity (≥98% by HPLC) and is supplied as a white to off-white crystalline powder. Its favorable pharmacokinetic properties, including good oral bioavailability and brain penetration, have made it a leading candidate for clinical trials in treatment-resistant depression and cognitive impairment. For B2B buyers, sourcing TAK-653 from a reliable supplier ensures consistent quality and timely delivery for your research needs.

製品の概要と成分

TAK-653 is a chemically synthesized compound with the molecular formula C₂₁H₁₉F₃N₄O₂ and a molecular weight of 416.4 g/mol. It is a trifluoromethyl-substituted pyrazole derivative, designed to selectively potentiate AMPA receptor signaling. The compound is highly lipophilic, which facilitates its penetration through the blood-brain barrier.

Our TAK-653 is produced via a multi-step organic synthesis process, followed by rigorous purification to achieve ≥98% purity. Each batch is thoroughly tested for identity, purity, and residual solvents to meet the demands of preclinical and clinical research. The product is available in various pack sizes to accommodate different scale requirements, from milligram quantities for initial screening to gram-scale for animal studies.

主な用途

• Neurological research: TAK-653 is widely used in studies of synaptic plasticity, long-term potentiation, and cognitive enhancement. It serves as a reference compound for AMPA receptor potentiation.
• Drug discovery: As a clinical-stage candidate, TAK-653 is employed in preclinical models of depression, schizophrenia, and Alzheimer’s disease to evaluate its therapeutic potential.
• Pharmacological tool: Researchers utilize TAK-653 to investigate the role of AMPA receptors in various brain functions, including memory formation and emotional regulation.
• Contract research organizations (CROs): CROs frequently require TAK-653 for clients’ projects, particularly in the areas of neuropharmacology and behavioral pharmacology.
• Pharmaceutical development: Companies developing next-generation ampakines may use TAK-653 as a benchmark to compare efficacy and safety profiles.

品質と基準

包装・供給

• パッケージ: TAK-653 is packaged in amber glass vials or aluminum foil bags, sealed under inert atmosphere to prevent degradation. Custom packaging options are available upon request.
• 最小注文数量（MOQ）: 10 mg for standard packs; larger quantities can be negotiated based on project needs.
• リードタイム: 3～5営業日（在庫品）
• ドキュメント: A comprehensive set of documents is provided, including Certificate of Analysis (COA), Material Safety Data Sheet (MSDS), and Technical Data Sheet (TDS). Additional documentation such as stability data and impurity profiles can be supplied for regulatory submissions.

見積依頼

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