Mosapride Citrate

同義語： Mosapride citrate, 112885-42-4, 4-Amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl]benzamide citrate, Gasmotin

Mosapride citrate is a prokinetic agent that selectively stimulates 5-HT4 receptors in the gastrointestinal tract. Its benzamide core, substituted with a 4-fluorobenzyl morpholine moiety, gives the molecule high affinity for serotonin receptor subtypes while avoiding significant interaction with dopamine D2 receptors. This selectivity underpins its clinical use for dyspepsia and gastroesophageal reflux, where it accelerates gastric emptying without the extrapyramidal side effects associated with older prokinetics.

The compound is synthesized through a multi-step route starting from 4-amino-5-chloro-2-ethoxybenzoic acid. The citrate salt form enhances aqueous solubility and stability, making it suitable for oral solid dosage forms. It is supplied as a fine crystalline powder with consistent particle size distribution, ideal for direct compression or wet granulation.

In pharmaceutical development, mosapride citrate serves as a reference standard and active ingredient for immediate-release tablets and suspensions. Its well-characterized pharmacokinetic profile—rapid absorption, extensive first-pass metabolism via CYP3A4—makes it a preferred model compound for studying prokinetic mechanisms and formulation strategies.

化学構造と性質

Mosapride citrate is a citrate salt of a benzamide derivative. The molecule features a 4-fluorobenzyl group attached to a morpholine ring, which is linked via a methylene bridge to the benzamide core. This structure confers lipophilicity and receptor selectivity. The citrate counterion improves crystallinity and dissolution rate. The compound is stable under normal storage conditions, with a melting point range of 148–152°C (decomposition).

作用機序

• 5-HT4 receptor agonism: Enhances acetylcholine release in the enteric nervous system, promoting peristalsis and gastric emptying.
• Selectivity: Minimal affinity for 5-HT3, dopamine D2, and adrenergic receptors, reducing off-target effects.
• Accelerated gastric emptying: Improves antral motility and coordination, beneficial in functional dyspepsia.
• No QT prolongation: Unlike some prokinetics, mosapride citrate has not shown significant cardiac conduction delays in clinical studies.

Quality Specifications (QC Tests)

供給および書類

• 容量: 5 metric tons per month
• リードタイム: 3～5営業日（在庫品）
• ドキュメント: COA, MSDS, TDS available upon request
• パッケージ: 25 kg fiber drum with double LDPE liner, or as per customer requirements

よくある質問

What is the minimum order quantity (MOQ)?

Our standard MOQ is 1 kg. For larger quantities, please contact our sales team for pricing and availability.

What is the delivery time?

For stock items, delivery is 3-5 business days from order confirmation. We ship globally via air or sea freight, depending on your location.

Do you provide a Certificate of Analysis (COA) and samples?

Yes, we provide a COA for each batch. Samples are available upon request, typically shipped within 1-2 days.

What are the packaging options?

We offer 25 kg fiber drums with double LDPE liners. Custom packaging is available to meet your specific needs.

Contact & Ordering Information

• Company: LyvBio Co., Ltd.
• Address: Room 5-0203, Courtyard 205, Lianhu District, Xi’an, Shaanxi, China
• Email: info@lyvbio.com
• Phone: +86-29-65816888

send us your specification for a quotation.