オルメサルタン・メドキソミル
| パラメータ | 仕様 |
|---|---|
| 製品名 | オルメサルタン・メドキソミル |
| CAS番号 | 144689-63-4 |
| 分子式 | C29H30N6O6 |
| 分子量 | 558.59 g/mol |
| 外観 | 白色からオフホワイトの結晶性粉末 |
| 分析（HPLC） | ≥99.0% (on dried basis) |
| 溶解度 | Slightly soluble in methanol, practically insoluble in water |
| パッケージ | 25 kg net in fiber drum with double polyethylene liner |
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同義語： Olmesartan medoxomil, Benicar, Olmetec, CS-866, RNH-6270, Olmesartan medoxomil impurity standard
Olmesartan medoxomil is a prodrug that belongs to the angiotensin II receptor blocker (ARB) class. Its molecular structure features a biphenyl-tetrazole scaffold with a medoxomil ester group, which masks the active carboxylic acid moiety. This design enhances oral bioavailability by facilitating absorption through the gastrointestinal tract, after which esterases rapidly hydrolyze the medoxomil group to release the active metabolite, olmesartan. The tetrazole ring and the biphenyl system are critical for high-affinity binding to the AT1 receptor, where it acts as a competitive antagonist.
As a selective AT1 receptor antagonist, olmesartan medoxomil is indicated for the treatment of hypertension, either alone or in combination with other antihypertensive agents. It is also used in research settings to study the renin-angiotensin system and its role in cardiovascular and renal diseases. The compound is typically manufactured under cGMP conditions and is available in various grades, including pharmaceutical grade and research grade.
In the pharmaceutical industry, olmesartan medoxomil is valued for its well-established efficacy, favorable safety profile, and long duration of action. It is often formulated into immediate-release tablets, and its patent landscape has led to numerous generic versions worldwide. For bulk purchasers, key considerations include assay purity, impurity profile, and particle size distribution to ensure consistent tableting performance.
Olmesartan medoxomil is a white to off-white crystalline powder with a molecular weight of 558.59 g/mol. It is practically insoluble in water but slightly soluble in methanol and other organic solvents. The medoxomil ester moiety makes the molecule more lipophilic, aiding in membrane permeability. The compound exists in a non-salt form and is typically micronized to improve dissolution rate. Its stability is pH-dependent; hydrolysis of the ester occurs under acidic or basic conditions, releasing the active olmesartan. The biphenyl-tetrazole core is responsible for the high selectivity towards the AT1 receptor, with minimal affinity for the AT2 subtype.
| Test Item | 仕様 |
|---|---|
| 識別 | IR, HPLC retention time conforms to reference standard |
| 乾燥減量 | ≤0.5% |
| 焼失残渣 | ≤0.11 TP3T |
| 重金属 | ≤20 ppm |
| 関連物質 | Any individual impurity ≤0.5%; total impurities ≤1.0% |
| Microbial Limits | Total aerobic count ≤1000 CFU/g; yeast and mold ≤100 CFU/g; absence of E. coli |
Our standard MOQ is 1 kg for trial orders, but we can accommodate smaller quantities for research purposes. For bulk orders, we recommend 25 kg to optimize shipping and handling.
For standard orders, lead time is 3-5 business days from receipt of purchase order. Expedited shipping options are available upon request, subject to availability.
Yes, we provide a COA for each batch. Samples of 10-50 g are available free of charge for quality evaluation, with the buyer covering shipping costs.
Learn more about our quality control and certifications, or send us your specification for a quotation.
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