Hydroxypinacolone Retinoate / Dimethyl Isosorbide

Sinonimi: Granactive Retinoid, HPR, Hydroxypinacolone Retinoate, Dimethyl Isosorbide, DMI, 2,5-Dimethyl-1,4:3,6-dianhydro-D-glucitol

In the ongoing search for retinoid alternatives that deliver visible results without the familiar drawbacks of irritation and instability, Hydroxypinacolone Retinoate (HPR) has emerged as a molecule of considerable interest. Unlike conventional retinol, which requires metabolic conversion, HPR is a direct ester of all-trans-retinoic acid, allowing it to interact with retinoid receptors without the same level of enzymatic activation. This has made it a sought-after ingredient for formulators targeting anti-aging, acne management, and skin texture improvement—particularly in products where mildness is a priority. Dimethyl isosorbide (DMI) complements HPR perfectly as a solvent and penetration enhancer, facilitating the delivery of HPR into the skin while also acting as a multifunctional ingredient in its own right.

Hydroxypinacolone Retinoate is a synthetic retinoid ester formed by the esterification of all-trans-retinoic acid with hydroxypinacolone. It appears as an off-white to pale yellow crystalline powder, practically insoluble in water but readily soluble in ethanol and oils. Dimethyl isosorbide, on the other hand, is a high-purity, water-miscible liquid derived from sorbitol. It acts as a solvent, carrier, and skin penetration enhancer, making it an ideal partner for HPR in topical formulations. Together, they represent a robust system for delivering retinoid benefits with reduced irritation potential.

Both materials are supplied at high purity—HPR at ≥98.0% (HPLC) and DMI at ≥99.0% (GC)—ensuring consistent performance in finished products. HPR is often standardized in DMI at a 10% concentration for ease of handling, but the pure powder is also available for those who prefer to formulate from scratch. The combination offers formulators a reliable route to stable, effective retinoid products that meet modern consumer expectations for both efficacy and tolerability.

Product Overview & Composition

Hydroxypinacolone Retinoate is a lipophilic ester that binds directly to retinoid receptors, bypassing the need for conversion to retinoic acid. This direct action is thought to contribute to its favorable irritation profile compared to retinol. Its molecular structure includes a hydroxypinacolone moiety, which enhances stability and reduces the likelihood of degradation during storage. Dimethyl isosorbide is a dipolar aprotic solvent with excellent solvency for a wide range of actives. It is often used to improve the spreadability and penetration of topical formulations, and it also serves as a co-solvent for HPR, ensuring even distribution in the final product.

In combination, these two ingredients offer a synergistic approach: DMI enhances the solubility and delivery of HPR, while HPR provides the retinoid activity. This pairing is particularly useful in serums, creams, and gels where a lightweight, non-greasy feel is desired. Both materials are compatible with common cosmetic ingredients and are generally regarded as safe for topical use.

Key Applications

• Anti-aging formulations: HPR is used in creams, serums, and lotions to reduce the appearance of fine lines and wrinkles, often in combination with peptides and antioxidants.
• Acne treatment: Due to its ability to regulate sebum production and keratinization, HPR is incorporated into acne-prone skin products, often with salicylic acid or niacinamide.
• Hyperpigmentation: HPR can help even skin tone by promoting cell turnover, making it a candidate for brightening products.
• Solubilizer and penetration enhancer: DMI is widely used to dissolve HPR and other poorly soluble actives, improving their bioavailability in topical applications.
• Stabilized retinoid systems: Pre-dissolved HPR in DMI (e.g., 10% solution) simplifies manufacturing and ensures uniform distribution in the final formulation.

Quality & Standards

Packaging & Supply

• Confezionamento: Hydroxypinacolone Retinoate is available in 1 kg aluminum foil bags, 5 kg cartons, or as a 10% solution in dimethyl isosorbide in 25 kg drums. Dimethyl isosorbide is supplied in 25 kg or 200 kg drums.
• MOQ: 1 kg for HPR powder; 25 kg for DMI.
• Tempi di consegna: 3-5 business days (stock items)
• Documentazione: COA, MSDS, TDS, and additional technical support available upon request.

Richiesta di preventivo

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