Aspirin

Sinonimi: Acetylsalicylic acid, ASA, 2-Acetoxybenzoic acid, Aspirinum, Ecotrin, Bufferin, Bayer Aspirin

Aspirin (acetylsalicylic acid) is one of the most widely recognized pharmaceutical actives in the world—a simple acetylated derivative of salicylic acid that has been used for over a century. While best known for its analgesic and antipyretic effects, its role as an irreversible inhibitor of cyclooxygenase (COX) has made it a cornerstone in cardiovascular prophylaxis, where low-dose aspirin remains the standard for secondary prevention of thrombotic events. For API buyers, aspirin represents a high-volume, well-characterized molecule with a mature supply chain and consistent global demand.

From a chemical standpoint, aspirin is a white, crystalline powder with a molecular weight of 180.16 g/mol. It is slightly soluble in water but freely soluble in ethanol and chloroform. The compound is stable under normal storage conditions but hydrolyzes to salicylic acid and acetic acid in the presence of moisture, which is why pharmacopeial monographs (USP, EP, BP) enforce strict limits on free salicylic acid. Unlike many modern APIs that require complex synthesis, aspirin is produced via a straightforward acetylation of salicylic acid with acetic anhydride, yielding a high-purity product that is easy to standardize.

Commercial aspirin is typically supplied as a USP/EP/BP-grade powder, with assay values between 99.0% and 101.0% on a dried basis. It is available in several particle sizes to suit direct compression, wet granulation, or suspension formulations. Beyond its use as a standalone active, aspirin is also a key starting material for the synthesis of other salicylates and serves as a reference standard in analytical laboratories. Its well-documented safety profile and low cost make it a preferred choice for generic manufacturers and contract development organizations.

Function & Mechanism

• Antiplatelet activity: Irreversibly acetylates COX-1 in platelets, reducing thromboxane A2 production and inhibiting platelet aggregation.
• Analgesic and antipyretic effects: Blocks prostaglandin synthesis in the CNS, alleviating pain and reducing fever.
• Anti-inflammatory action: At higher doses, inhibits COX-2 and reduces inflammatory mediators in peripheral tissues.
• Cardiovascular prophylaxis: Low-dose aspirin is widely prescribed for secondary prevention of myocardial infarction and ischemic stroke.
• Chemopreventive potential: Long-term use has been associated with reduced risk of certain gastrointestinal cancers in clinical studies.

Fonte e standardizzazione

• Fonte: Synthetic, derived from salicylic acid and acetic anhydride.
• Extraction: Not applicable; produced via chemical acetylation and subsequent crystallization.
• Standardizzazione: USP, EP, BP, JP monographs; assay 99.0–101.0% (HPLC, anhydrous basis).
• Moduli: White crystalline powder, granular, or fine powder; typical particle size distributions available.
• Applicazioni: Tablet and capsule manufacturing, effervescent formulations, veterinary medicine, analytical reference standards.

Quality Specifications (QC Tests)

Bulk Supply & Documentation

• Capacità mensile: 50 metric tons
• Tempi di consegna: 3-5 business days (stock items)
• Documentazione: COA, MSDS, TDS, DMF available upon request
• Confezionamento: 25 kg fiber drums with double polyethylene liners; customized packaging available

Frequently Asked Questions

What is the minimum order quantity for Aspirin?

Our standard MOQ is 100 kg, but we can accommodate smaller trial orders for qualified customers.

Do you provide samples for evaluation?

Yes, we offer free samples of up to 100 g for laboratory testing. Customers are responsible for shipping costs.

What is the shelf life and storage recommendation?

When stored in a cool, dry place in tightly sealed containers away from direct sunlight, the shelf life is 24 months from the date of manufacture.

Contact & Ordering Information

• Company: LyvBio Co., Ltd.
• Address: Room 5-0203, Courtyard 205, Lianhu District, Xi’an, Shaanxi, China
• Email: info@lyvbio.com
• Phone: +86-29-65816888

Learn more about our quality control and certifications, or send us your specification for a quotation.