{"id":1903,"date":"2026-10-17T20:57:52","date_gmt":"2026-10-17T12:57:52","guid":{"rendered":"https:\/\/www.lyvbio.com\/?p=1903"},"modified":"2026-10-17T20:59:28","modified_gmt":"2026-10-17T12:59:28","slug":"hydroxypinacolone-retinoate-hpr-the-next-generation-retinoid-for-modern-formulators","status":"publish","type":"post","link":"https:\/\/www.lyvbio.com\/es\/hydroxypinacolone-retinoate-hpr-the-next-generation-retinoid-for-modern-formulators\/","title":{"rendered":"Hydroxypinacolone Retinoate (HPR): The Next-Generation Retinoid for Modern Formulators"},"content":{"rendered":"<p><strong><span class=\"\">Product Name:<\/span><\/strong><span class=\"\">\u00a0<a href=\"https:\/\/www.lyvbio.com\/products\/hydroxypinacolone-retinoate\/\">Hydroxypinacolone Retinoate<\/a><\/span><br \/>\n<strong><span class=\"\">CAS Number:<\/span><\/strong><span class=\"\">\u00a0893412-73-2<\/span><br \/>\n<strong><span class=\"\">Denominaci\u00f3n INCI:<\/span><\/strong><span class=\"\">\u00a0Hydroxypinacolone Retinoate<\/span><br \/>\n<strong><span class=\"\">F\u00f3rmula molecular:<\/span><\/strong><span class=\"\">\u00a0C24H36O3<\/span><br \/>\n<strong><span class=\"\">Peso molecular:<\/span><\/strong><span class=\"\">\u00a0372.54<\/span><br \/>\n<strong><span class=\"\">Aspecto:<\/span><\/strong><span class=\"\">\u00a0Light yellow to yellow powder<\/span><br \/>\n<strong><span class=\"\">Assay:<\/span><\/strong><span class=\"\">\u00a099.0% Min<\/span><br \/>\n<strong><span class=\"\">M\u00e9todo de ensayo:<\/span><\/strong><span class=\"\">\u00a0HPLC<\/span><br \/>\n<strong><span class=\"\">Solubility:<\/span><\/strong><span class=\"\">\u00a0Soluble in ethanol and oils, insoluble in water<\/span><br \/>\n<strong><span class=\"\">Storage:<\/span><\/strong><span class=\"\">\u00a0Store in a cool, dry place, sealed, protected from light and moisture<\/span><br \/>\n<strong><span class=\"\">Sin\u00f3nimos:<\/span><\/strong><span class=\"\">\u00a0Hydroxypinacolone Retinoate, HPR, Hydroxypinacolone Retinoate Powder, Retinoic Acid Ester<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Sin\u00f3nimos:<\/span><\/strong><span class=\"\">\u00a0Hydroxypinacolone Retinoate, HPR, Granactive Retinoid, Retinoic Acid Ester, 3,3-Dimethyl-2-oxobutyl Retinoate, Hydroxypinacolone Retinoate (HPR), Retinyl Hydroxypinacolone<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Need help? Contact our team<\/span><\/strong><\/p>\n<hr \/>\n<h2><span class=\"\">Descripci\u00f3n<\/span><\/h2>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Hydroxypinacolone Retinoate (HPR) is a next-generation retinoid and a stable ester of retinoic acid. Unlike conventional retinoids such as retinol or tretinoin, HPR is a\u00a0<\/span><strong><span class=\"\">direct retinoic acid receptor (RAR) agonist<\/span><\/strong><span class=\"\">, meaning it binds directly to retinoic acid receptors without requiring metabolic conversion. This direct action allows HPR to deliver the benefits of retinoic acid while maintaining superior stability and significantly lower irritation potential.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">HPR is considered a &#8220;granactive retinoid&#8221; \u2014 a term used to describe retinoid esters that provide retinoic acid-like effects with enhanced tolerability. Because it binds directly to RARs, HPR bypasses the conversion steps required by retinol and retinyl esters, which can be inefficient and variable among individuals.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">HPR is widely used in anti-aging, acne-treatment, and skin-resurfacing formulations. It is compatible with a broad range of cosmetic ingredients and is stable in both emulsion and anhydrous systems, making it a preferred choice for formulators seeking a high-performance, low-irritation retinoid.<\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-1900\" src=\"https:\/\/www.lyvbio.com\/wp-content\/uploads\/2026\/10\/893412-73-2.gif\" alt=\"\" width=\"562\" height=\"146\" \/><\/p>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">If you work in cosmetic formulation, you already know that retinoids are the gold standard for skin renewal. But you also know the pain points: irritation, instability, and the tricky balance between efficacy and tolerability. Hydroxypinacolone Retinoate, commonly known as HPR, has been gaining attention as a next-generation retinoid that addresses many of these challenges. Here is a practical look at what HPR is, why it stands out, and what formulators should keep in mind.<\/span><\/p>\n<p><a href=\"https:\/\/www.lyvbio.com\/products\/hydroxypinacolone-retinoate\/\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-1902 size-full\" title=\"Hydroxypinacolone Retinoate\" src=\"https:\/\/www.lyvbio.com\/wp-content\/uploads\/2026\/10\/HPR-yellow.jpg\" alt=\"\" width=\"750\" height=\"750\" srcset=\"https:\/\/www.lyvbio.com\/wp-content\/uploads\/2026\/10\/HPR-yellow.jpg 750w, https:\/\/www.lyvbio.com\/wp-content\/uploads\/2026\/10\/HPR-yellow-300x300.jpg 300w, https:\/\/www.lyvbio.com\/wp-content\/uploads\/2026\/10\/HPR-yellow-150x150.jpg 150w, https:\/\/www.lyvbio.com\/wp-content\/uploads\/2026\/10\/HPR-yellow-12x12.jpg 12w\" sizes=\"auto, (max-width: 750px) 100vw, 750px\" \/><\/a><\/p>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">In its raw form, HPR appears as a light yellow to yellow powder. It is oil-soluble and ethanol-soluble, but practically insoluble in water. For formulation, it is usually supplied as a powder or pre-diluted in a carrier oil.<\/span><\/p>\n<h2 class=\"ds-markdown-paragraph\"><strong><span class=\"\">Why Formulators Are Interested in HPR<\/span><\/strong><\/h2>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">The main appeal of HPR comes down to three practical factors.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">First,\u00a0<\/span><strong><span class=\"\">tolerability<\/span><\/strong><span class=\"\">. Retinol and retinoic acid are notorious for causing redness, peeling, and stinging, especially in beginners. HPR is generally reported to be gentler on the skin barrier, which makes it easier to incorporate into daily-use products for a wider range of skin types.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Second,\u00a0<\/span><strong><span class=\"\">stability<\/span><\/strong><span class=\"\">. Retinol is highly sensitive to light, heat, and oxygen. HPR shows better stability in formulation, which means less risk of color change or loss of activity during shelf life. This is a significant advantage for brands looking to extend product stability without overly complex packaging.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">Third,\u00a0<\/span><strong><span class=\"\">formulation flexibility<\/span><\/strong><span class=\"\">. Because HPR is oil-soluble and relatively stable, it fits well into anhydrous systems, emulsions, and oil serums. It does not require the same low-pH environment that some retinol formulations demand.<\/span><\/p>\n<h2 class=\"ds-markdown-paragraph\"><strong><span class=\"\">What the Market Is Doing<\/span><\/strong><\/h2>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">HPR is not a new molecule, but its commercial visibility has grown significantly in recent years. It is often marketed under trade names and appears in premium anti-aging serums, eye creams, and night treatments. In the B2B space, buyers typically look for HPR in two forms: high-purity powder (99% min) for custom formulation, and pre-diluted solutions for easier handling.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">When sourcing HPR, purity and assay are critical. A 99% HPLC assay is the standard benchmark for cosmetic-grade material. Suppliers should provide a full COA, including residual solvents and heavy metals, because retinoid esters are sensitive to impurities that can affect both stability and skin tolerance.<\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-1905\" src=\"https:\/\/www.lyvbio.com\/wp-content\/uploads\/2026\/10\/Hydroxypinacolone-Retinoate-blog.jpg\" alt=\"\" width=\"750\" height=\"400\" srcset=\"https:\/\/www.lyvbio.com\/wp-content\/uploads\/2026\/10\/Hydroxypinacolone-Retinoate-blog.jpg 750w, https:\/\/www.lyvbio.com\/wp-content\/uploads\/2026\/10\/Hydroxypinacolone-Retinoate-blog-300x160.jpg 300w, https:\/\/www.lyvbio.com\/wp-content\/uploads\/2026\/10\/Hydroxypinacolone-Retinoate-blog-150x80.jpg 150w, https:\/\/www.lyvbio.com\/wp-content\/uploads\/2026\/10\/Hydroxypinacolone-Retinoate-blog-18x10.jpg 18w\" sizes=\"auto, (max-width: 750px) 100vw, 750px\" \/><\/p>\n<h2 class=\"ds-markdown-paragraph\"><strong><span class=\"\">Formulation Notes<\/span><\/strong><\/h2>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">A few practical points for formulators working with HPR:<\/span><\/p>\n<ul>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Solubilidad<\/span><\/strong><span class=\"\">: HPR is oil-soluble. It should be dissolved in the oil phase before emulsification. For anhydrous systems, it can be incorporated directly into the oil carrier.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Processing temperature<\/span><\/strong><span class=\"\">: Keep processing temperatures moderate. While HPR is more stable than retinol, excessive heat can still degrade the molecule.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Embalaje<\/span><\/strong><span class=\"\">: Use opaque or UV-protective packaging. Even with improved stability, light protection remains essential for retinoid esters.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">pH range<\/span><\/strong><span class=\"\">: HPR does not require the low pH that retinol does, but it is still best to keep the final formulation within a moderate pH range to maintain stability.<\/span><\/p>\n<\/li>\n<li>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Compatibility<\/span><\/strong><span class=\"\">: Avoid strong oxidizing agents and incompatible actives that could accelerate degradation.<\/span><\/p>\n<\/li>\n<\/ul>\n<h2 class=\"ds-markdown-paragraph\"><strong><span class=\"\">Regulatory and Labeling Considerations<\/span><\/strong><\/h2>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">HPR is classified as a cosmetic ingredient in most markets, but labeling rules vary by region. In the EU, it falls under cosmetic regulation, and claims must be substantiated. In the US, it is used as a cosmetic ingredient, but any anti-aging or anti-wrinkle claims must comply with FTC guidelines. In China, cosmetic ingredients must be listed in the Inventory of Existing Cosmetic Ingredients in China (IECIC), and new ingredients require registration.<\/span><\/p>","protected":false},"excerpt":{"rendered":"<p>Product Name:\u00a0Hydroxypinacolone Retinoate CAS Number:\u00a0893412-73-2 INCI Name:\u00a0Hydroxypinacolone Retinoate Molecular Formula:\u00a0C24H36O3 Molecular Weight:\u00a0372.54 Appearance:\u00a0Light yellow to yellow powder Assay:\u00a099.0% Min Test Method:\u00a0HPLC Solubility:\u00a0Soluble in ethanol and oils, insoluble in water Storage:\u00a0Store in a cool, dry place, sealed, protected from light and moisture Synonyms:\u00a0Hydroxypinacolone Retinoate, HPR, Hydroxypinacolone Retinoate Powder, Retinoic Acid Ester Synonyms:\u00a0Hydroxypinacolone Retinoate, HPR, Granactive Retinoid, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1904,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[13],"tags":[],"product_tag":[],"class_list":["post-1903","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Hydroxypinacolone Retinoate (HPR): The Next-Generation Retinoid for Modern Formulators | LyvBio Co,.Ltd<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.lyvbio.com\/es\/hydroxypinacolone-retinoate-hpr-the-next-generation-retinoid-for-modern-formulators\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hydroxypinacolone Retinoate (HPR): The Next-Generation Retinoid for Modern Formulators | LyvBio Co,.Ltd\" \/>\n<meta property=\"og:description\" content=\"Product Name:\u00a0Hydroxypinacolone Retinoate CAS Number:\u00a0893412-73-2 INCI Name:\u00a0Hydroxypinacolone Retinoate Molecular Formula:\u00a0C24H36O3 Molecular Weight:\u00a0372.54 Appearance:\u00a0Light yellow to yellow powder Assay:\u00a099.0% Min Test Method:\u00a0HPLC Solubility:\u00a0Soluble in ethanol and oils, insoluble in water Storage:\u00a0Store in a cool, dry place, sealed, protected from light and moisture Synonyms:\u00a0Hydroxypinacolone Retinoate, HPR, Hydroxypinacolone Retinoate Powder, Retinoic Acid Ester Synonyms:\u00a0Hydroxypinacolone Retinoate, HPR, Granactive Retinoid, [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.lyvbio.com\/es\/hydroxypinacolone-retinoate-hpr-the-next-generation-retinoid-for-modern-formulators\/\" \/>\n<meta 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Co,.Ltd","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.lyvbio.com\/es\/hydroxypinacolone-retinoate-hpr-the-next-generation-retinoid-for-modern-formulators\/","og_locale":"es_ES","og_type":"article","og_title":"Hydroxypinacolone Retinoate (HPR): The Next-Generation Retinoid for Modern Formulators | LyvBio Co,.Ltd","og_description":"Product Name:\u00a0Hydroxypinacolone Retinoate CAS Number:\u00a0893412-73-2 INCI Name:\u00a0Hydroxypinacolone Retinoate Molecular Formula:\u00a0C24H36O3 Molecular Weight:\u00a0372.54 Appearance:\u00a0Light yellow to yellow powder Assay:\u00a099.0% Min Test Method:\u00a0HPLC Solubility:\u00a0Soluble in ethanol and oils, insoluble in water Storage:\u00a0Store in a cool, dry place, sealed, protected from light and moisture Synonyms:\u00a0Hydroxypinacolone Retinoate, HPR, Hydroxypinacolone Retinoate Powder, Retinoic Acid Ester Synonyms:\u00a0Hydroxypinacolone Retinoate, HPR, Granactive Retinoid, [&hellip;]","og_url":"https:\/\/www.lyvbio.com\/es\/hydroxypinacolone-retinoate-hpr-the-next-generation-retinoid-for-modern-formulators\/","og_site_name":"LyvBio Co,.Ltd","article_published_time":"2026-10-17T12:57:52+00:00","article_modified_time":"2026-10-17T12:59:28+00:00","og_image":[{"width":750,"height":400,"url":"https:\/\/www.lyvbio.com\/wp-content\/uploads\/2026\/10\/HPR-blog.jpg","type":"image\/jpeg"}],"author":"Danielle Dobson","twitter_card":"summary_large_image","twitter_misc":{"Escrito por":"Danielle Dobson","Tiempo de lectura":"6 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