TUDCA

Tauroursodeoxycholic Acid (TUDCA, 99% Purity)

1. Synonyms: Tauroursodeoxycholic Acid, TUDCA, Tauroursodeoxycholate, Ursodeoxycholic Acid Taurine Conjugate, Taurine Conjugate of Ursodeoxycholic Acid, 3α,7β-Dihydroxy-5β-cholan-24-oyltaurine, (3α,5β,7β)-3,7-Dihydroxy-cholan-24-oic Acid N-(2-Sulfoethyl)amide

Tauroursodeoxycholic Acid (TUDCA) is a hydrophilic bile acid, formed by the conjugation of ursodeoxycholic acid (UDCA) with the amino acid taurine. It is a naturally occurring bile acid found in small amounts in human bile and is produced by the liver. TUDCA is the taurine-conjugated form of UDCA and is more hydrophilic than its parent compound, which contributes to its unique biological activities.

TUDCA has attracted considerable scientific interest for its neuroprotective, hepatoprotective, and cytoprotective properties. It functions by inhibiting apoptosis (programmed cell death) through the stabilization of mitochondria and the suppression of the mitochondrial apoptotic pathway. This mechanism is particularly relevant in conditions associated with endoplasmic reticulum stress and mitochondrial dysfunction.

TUDCA is widely used in research on liver health, neuroprotection, and metabolic disorders. It is one of the most extensively studied bile acid derivatives, with a growing body of evidence supporting its potential in treating cholestatic liver diseases, neurodegenerative conditions, and retinal disorders.

Function

• Apoptosis inhibition: Stabilizes mitochondria, blocks the mitochondrial apoptotic pathway.

• ER stress reduction: Attenuates endoplasmic reticulum stress.

• Hepatoprotective effects: Supports liver function in cholestatic conditions.

• Neuroprotective activity: Protects neurons from stress-induced apoptosis.

• Mitochondrial support: Maintains mitochondrial membrane integrity and function.

• Anti-inflammatory activity: Modulates inflammatory pathways.

Source & Purity

• Source: Synthetic production (from ursodeoxycholic acid and taurine)

• Standardization: ≥99.0% TUDCA (HPLC)

• Forms: White to off-white crystalline powder

• Applications: Research, dietary supplements, pharmaceutical formulations, neuroprotection studies

Specifications