4-(4-(cyclopentyloxy)quinolin-2- yl)benzene-1,2-diol (CMS121)

Synonyms: CMS121; 4-(4-(Cyclopentyloxy)quinolin-2-yl)-1,2-benzenediol; 4-[4-(Cyclopentyloxy)-2-quinolinyl]-1,2-benzenediol; CMS-121

Neurodegenerative diseases such as Alzheimer’s and Parkinson’s continue to drive demand for small molecules that can modulate multiple pathological pathways. CMS121 has drawn considerable interest in the research community as a next-generation neuroprotective candidate, with preclinical data supporting its potential in cognitive health and age-related disorders. The compound is increasingly requested by laboratories and formulation scientists exploring new therapeutic avenues.

CMS121 is a synthetic small molecule derived from fisetin, a natural flavonoid found in fruits and vegetables. It features a quinoline core with a cyclopentyloxy substituent and a catechol moiety, which together enhance its metabolic stability and blood-brain barrier penetration compared to the parent compound. The structure-activity relationship studies have shown that these modifications significantly improve its pharmacological profile.

LyvBio supplies CMS121 with purity of 98% or higher, as determined by HPLC. Each batch is thoroughly tested to ensure consistent quality and reliable performance in research applications. The compound is available in milligram to gram quantities, with custom packaging options to meet specific research needs.

Product Overview & Composition

CMS121 is a synthetic analog of fisetin, designed to improve upon the natural compound’s limitations. The introduction of a cyclopentyloxy group at the 4-position of the quinoline ring and the presence of a catechol group contribute to its unique chemical and biological properties. The molecular formula is C₂₀H₁₉NO₃, with a molecular weight of 321.37 g/mol.

The compound is typically synthesized through a multi-step process, starting from commercially available quinoline derivatives. Its purity is confirmed by HPLC, and structural identity is verified by NMR and mass spectrometry. CMS121 is stable under recommended storage conditions and is compatible with common organic solvents used in research.

Key Applications

• Neurodegenerative disease research: Investigated for its ability to reduce oxidative stress and inflammation in neuronal cells, with potential applications in Alzheimer’s and Parkinson’s disease models.
• Cognitive health studies: Explored for its effects on memory and learning in preclinical models, possibly through modulation of signaling pathways involved in synaptic plasticity.
• Anti-aging research: Studied for its senolytic and anti-inflammatory properties, which may influence cellular senescence and age-related decline.
• Metabolic disorders: Evaluated for its impact on metabolic parameters such as insulin sensitivity and lipid profiles in animal studies.
• Pharmacological tool: Used as a reference compound in studies of quinoline-based derivatives and their biological activities.

Quality & Standards

Packaging & Supply

• Packaging: Amber glass vials with PTFE-lined caps, sealed under argon; custom packaging available upon request.
• MOQ: 10 mg
• Lead time: 3-5 business days for in-stock items; 2-3 weeks for bulk orders.
• Documentation: COA, MSDS, TDS provided with each shipment.

Request For Quote

• LyvBio Co., Ltd. — Email: info@lyvbio.com