Calcium Hopantenate

Synonyms: Calcium N-(2-hydroxy-3,3-dimethylbutyryl)-β-alaninate, Calcium hopantenate, Hopantenic acid calcium salt, Calcium homopantothenate, Ca-HOPA

Calcium hopantenate is a synthetic calcium salt of hopantenic acid, a derivative of D-pantothenic acid (vitamin B5) in which the β-alanine moiety is extended by one methylene group. This structural modification yields a compound with enhanced lipophilicity and improved blood-brain barrier penetration compared to pantothenic acid. The molecule features a characteristic amide bond linking the hydroxy acid to the β-alanine backbone, with the calcium ion providing stability and water solubility.

First synthesized in Japan in the 1960s, calcium hopantenate has been investigated for its nootropic and neuroprotective properties. It is commonly supplied as a white crystalline powder with high purity, typically ≥98% as determined by HPLC. The compound is available in research-grade quantities for pharmaceutical and biochemical applications.

In the pharmaceutical and nutraceutical industries, calcium hopantenate is primarily used as an active pharmaceutical ingredient (API) in formulations targeting cognitive enhancement and neurological support. Its ability to modulate neurotransmitter systems, particularly GABA and acetylcholine, underpins its potential in managing conditions such as memory impairment and age-related cognitive decline. Additionally, it serves as a reference standard in analytical laboratories and as a building block in medicinal chemistry research.

Chemical Structure & Properties

Calcium hopantenate, with the molecular formula C10H18CaN2O5 and a molecular weight of 286.34 g/mol, is a calcium salt of (R)-N-(2-hydroxy-3,3-dimethylbutyryl)-β-alanine. The structure comprises a 2-hydroxy-3,3-dimethylbutyryl group linked via an amide bond to β-alanine, with the calcium ion balancing the carboxylate charge. This configuration confers high water solubility and stability under normal storage conditions. The compound is optically active, with the (R)-enantiomer being the biologically relevant form.

Mechanism of Action

• GABAergic modulation: Calcium hopantenate enhances GABA synthesis and release, potentially improving neuronal inhibition and reducing excitotoxicity.
• Cholinergic potentiation: It may increase acetylcholine levels in the brain by promoting choline uptake and acetyltransferase activity, supporting cognitive function.
• Neuroprotective effects: The compound exhibits antioxidant properties, scavenging free radicals and mitigating oxidative stress in neural tissues.
• Mitochondrial support: As a pantothenic acid derivative, it may support coenzyme A synthesis, enhancing cellular energy metabolism.

Quality Specifications

Supply & Documentation

• Capacity: Monthly production capacity of 500 kg, scalable upon request.
• Lead time: 3-5 business days (stock items)
• Documentation: COA, MSDS, TDS provided with each shipment.
• Packaging: 25 kg fiber drums with double polyethylene liners, or customized packaging for small quantities.

Request For Quote

• LyvBio Co., Ltd. — Email: info@lyvbio.com