Berberine Hydrochloride

Synonyms

Berberine Hydrochloride, Berberine HCl, Berberine Chloride Hydrochloride, Natural Yellow 18, C.I. 75160, Umbellatine Hydrochloride

Berberine Hydrochloride is the hydrochloride salt form of berberine, a naturally occurring isoquinoline alkaloid found in several medicinal plants, including Coptis chinensis (Chinese goldthread), Hydrastis canadensis (goldenseal), Berberis aristata (tree turmeric), and Phellodendron amurense (Amur cork tree).

It has been a cornerstone of Traditional Chinese Medicine (TCM) and Ayurvedic medicine for centuries, valued for its broad-spectrum antimicrobial and anti-inflammatory properties.

BERBERINE-HYDROCHLORIDE-N-HYDRATE

In recent decades, berberine has attracted significant scientific attention for its diverse pharmacological activities, particularly its ability to activate AMP-activated protein kinase (AMPK), a key regulator of cellular energy homeostasis. This mechanism underpins its potential in metabolic health, glucose and lipid metabolism, and cardiovascular support.

Berberine is one of the most extensively studied natural alkaloids, with hundreds of clinical trials investigating its efficacy in various conditions.

Berberine hydrochloride is the preferred form for supplementation and research due to its enhanced stability and consistent bioavailability compared to other berberine salts or extracts.

Function

• AMPK activator: Activates the master metabolic regulator, promoting glucose uptake and fatty acid oxidation.

• Metabolic support: Improves insulin sensitivity and lipid profile.

• Antimicrobial activity: Broad-spectrum activity against bacteria, fungi, and protozoa.

• Anti-inflammatory effects: Modulates inflammatory pathways, including NF-κB.

• Antioxidant activity: Scavenges reactive oxygen species (ROS).

• Cardiovascular support: Supports healthy cholesterol levels and vascular function.

Purity

• Source: Coptis chinensis (Chinese goldthread), Hydrastis canadensis (goldenseal), Berberis aristata

• Standardization: ≥98.0% berberine hydrochloride (HPLC)

• Forms: Yellow crystalline powder (pharmaceutical-grade and research-grade available)

• Applications: Dietary supplements, pharmaceutical research, and traditional medicine formulations

Specifications