Grape Seed Extract

Grape Seed Extract is a standardized botanical concentrate derived from the seeds of Vitis vinifera (wine grapes).

It is one of the richest natural sources of oligomeric proanthocyanidins (OPC) , a class of bioflavonoid compounds consisting of monomeric, dimeric, and oligomeric flavan-3-ols (catechin and epicatechin units). The extract is standardized to a minimum of 95% proanthocyanidins by UV-Vis spectrophotometry.

Proanthocyanidins are distinguished by their ability to bind and cross-link proteins, which underpins their unique bioactivities, including collagen stabilization, capillary integrity enhancement, and potent free radical scavenging activity. The oligomeric nature of these compounds influences their bioavailability and biological activity.

Grape Seed Extract (OPC 95%) is one of the most thoroughly studied botanical ingredients, with decades of clinical and pharmacological research supporting its use in cardiovascular health, skin health, joint support, and cognitive function applications.

Function

• Antioxidant activity: Potent free radical scavenging capacity, particularly against peroxyl radicals and superoxide anions.

• Collagen stabilization: Cross‑links with collagen and elastin, supporting vascular integrity and dermal structure.

• Cardiovascular support: Enhances microcirculation, capillary permeability, and venous tone.

• Anti‑inflammatory activity: Modulates the arachidonic acid cascade and COX/LOX pathways.

• Enzyme inhibition: Inhibits matrix metalloproteinases (MMPs), elastase, and hyaluronidase.

• Skin health: Supports skin elasticity, hydration, and UV protection.

Source & Standardization

• Source: Seeds of Vitis vinifera (wine grapes)

• Extraction: Water or hydroalcoholic extraction, followed by concentration and drying

• Standardization: ≥95.0% proanthocyanidins (UV‑Vis)

• Forms: Reddish‑brown to purple‑brown fine powder

Frequently Asked Questions

Q: What is the difference between grape seed extract and grape skin extract?
A: Grape seed extract is rich in proanthocyanidins (OPC), while grape skin extract contains higher levels of resveratrol and anthocyanins. Both are beneficial but have different polyphenol profiles.

Q: What is OPC and why is it important?
A: OPC stands for oligomeric proanthocyanidins, a class of bioflavonoids with potent antioxidant activity. They help stabilize collagen, support cardiovascular health, and protect against oxidative stress.

Q: Is grape seed extract suitable for vegetarians?
A: Yes, grape seed extract is plant‑derived and suitable for vegetarian and vegan formulations.

Q: How is grape seed extract standardized?
A: Our grape seed extract is standardized to ≥95% proanthocyanidins by UV‑Vis spectrophotometry.

Q: What is the recommended dosage for cardiovascular support?
A: Clinical studies typically use 100 – 300 mg per day, standardized to ≥95% OPC.