Hesperidin methylchalcone

Hesperidin methylchalcone (CAS 24292-52-2) is a semi-synthetic flavonoid derivative obtained by methylation and chalcone rearrangement of hesperidin, a natural flavanone glycoside abundant in citrus peels. This modification enhances its lipophilicity and metabolic stability, making it a preferred active ingredient in oral and topical formulations targeting vascular and lymphatic support. Supplied as a pale yellow crystalline powder with ≥98% purity by HPLC, each batch is accompanied by COA, MSDS, and TDS.

With a well-documented safety profile and growing clinical evidence, Hesperidin methylchalcone is widely used in dietary supplements, cosmeceuticals, and pharmaceutical research. Its ability to strengthen capillary resistance and improve microcirculation makes it a valuable addition to formulations for leg heaviness, edema, and overall circulatory health.

Synonyms: Hesperetin methylchalcone, 2′,3,4-trihydroxy-4′-methoxy-3′-methylchalcone 7-rhamnoglucoside, HMC, Methylchalcone hesperidin, Hesperidin methyl chalcone

Applications

• Vascular health supplements targeting capillary fragility and chronic venous insufficiency
• Topical creams and gels for reducing under-eye circles and edema
• Functional beverages and nutraceuticals for microcirculation support
• R&D use in pharmacological studies on anti-inflammatory and antioxidant pathways

Quality & Documentation

Every batch is tested for assay (HPLC ≥98%), loss on drying (≤5.0%), and heavy metals (≤10 ppm). Full COA, MSDS, and TDS are available on request; stability data can be provided for qualification.

Packaging & Supply

Standard packaging: 1 kg, 5 kg, 25 kg; bulk and custom packing available. In-stock items ship within 3-5 days; MOQ from 1 kg. For pricing, samples and bulk orders, contact our sales team.

Request For Quote

• Our Address: 280 Main Street, Xian, Shaanxi, China
• LyvBio Co., Ltd. — Email: info@lyvbio.com