L-Methylfolate

Synonyms: L-5-MTHF, Levomefolic acid, (6S)-5-Methyltetrahydrofolate, L-5-Methyltetrahydrofolate, Metafolin, 5-MTHF

L-Methylfolate is the biologically active form of folate, featuring a fully reduced pteridine ring with a methyl group at the N5 position and a para-aminobenzoic acid (PABA) moiety conjugated to a glutamate residue. This structure enables it to serve as the primary methyl donor in the remethylation of homocysteine to methionine, a reaction catalyzed by methionine synthase. Unlike folic acid, which requires enzymatic reduction by dihydrofolate reductase (DHFR), L-methylfolate bypasses this step, offering direct bioavailability. It is commercially produced via chemical or enzymatic synthesis, yielding a stable, crystalline salt (typically calcium or glucosamine salt) that is standardized for pharmaceutical and nutraceutical applications.

The compound is widely used in dietary supplements, functional foods, and clinical nutrition, particularly for individuals with MTHFR gene polymorphisms that impair folate metabolism. Its applications extend to prenatal care, cardiovascular health, and cognitive support, where it supports normal homocysteine levels and neurotransmitter synthesis. As a bulk ingredient, L-Methylfolate is supplied under strict quality control, with specifications ensuring high purity and consistent performance in finished formulations.

Chemical Structure & Properties

L-Methylfolate is a chiral molecule with a molecular formula of C20H25N7O6 and a molecular weight of 459.46 g/mol. It appears as a white to off-white crystalline powder, soluble in water and slightly soluble in ethanol. The compound is sensitive to light and oxidation, requiring storage under inert atmosphere and protection from moisture. Its stability is enhanced in salt form, such as calcium L-methylfolate or glucosamine L-methylfolate, which are commonly used in commercial preparations.

Mechanism of Action

• Methyl donor: Participates in the methionine synthase reaction, converting homocysteine to methionine and supporting methylation processes.
• DNA synthesis: Provides methyl groups for thymidylate and purine synthesis, essential for cell division.
• Neurotransmitter synthesis: Cofactor in the synthesis of serotonin, dopamine, and norepinephrine.
• Endothelial function: Helps reduce homocysteine levels, supporting vascular health.

Quality Specifications

Supply & Documentation

• Capacity: 5 MT per month
• Lead time: 3-5 business days (stock items)
• Documentation: COA, MSDS, TDS available upon request
• Packaging: 1 kg, 5 kg, 10 kg, 25 kg fiber drums with double polyethylene liners

Request For Quote

• LyvBio Co., Ltd. — Email: info@lyvbio.com