Hexapeptide-2

Synonyms: Hexapeptide-2, H-6, Melanostatin DM, CAS 87616-84-0

Hexapeptide-2 is a synthetic peptide consisting of six amino acids, with the sequence His-D-Phe-Arg-Trp-D-Phe-Lys. It is a structural analog of the endogenous neuropeptide melanostatin (MIF-1, Pro-Leu-Gly-NH2), modified to enhance stability and receptor affinity. In the personal care industry, it is recognized as a melanin-regulating active that addresses pigmentation disorders and uneven skin tone without the cytotoxicity associated with traditional depigmenting agents like hydroquinone.

Unlike many peptides that focus solely on collagen stimulation or barrier repair, Hexapeptide-2 works by modulating melanogenesis at the source. It acts as an antagonist of the melanocortin-1 receptor (MC1R), competing with α-melanocyte-stimulating hormone (α-MSH) for binding. This competitive inhibition reduces tyrosinase activity and subsequent melanin production, making it a targeted solution for hyperpigmentation, melasma, and post-inflammatory hyperpigmentation (PIH).

Formulators value Hexapeptide-2 for its compatibility with a wide range of cosmetic ingredients and its favorable safety profile. It is water-soluble, stable in formulations at pH 5.0–7.0, and effective at low concentrations (typically 0.001–0.01%). Clinical studies have demonstrated significant reductions in melanin content and improved skin tone evenness after 8–12 weeks of twice-daily application. While primarily used in skin-lightening and brightening products, it is also incorporated into anti-aging formulations for its role in preventing UV-induced pigmentation.

Function

• Melanin regulation: Inhibits melanin synthesis by blocking MC1R and reducing tyrosinase activity.
• Skin brightening: Fades existing dark spots and prevents new ones from forming.
• Anti-inflammatory: Reduces inflammation-induced pigmentation (PIH).
• Antioxidant: Scavenges free radicals to protect melanocytes from oxidative stress.
• Even skin tone: Promotes uniform complexion by regulating melanin distribution.

Source & Standardization

• Source: Synthetic peptide produced via solid-phase peptide synthesis (SPPS).
• Purity: ≥98% (HPLC).
• Standardization: Each batch is tested for assay, appearance, solubility, and heavy metals.
• Forms: White to off-white powder.
• Applications: Skin-lightening serums, brightening creams, anti-aging formulations, and research.

Specifications

Documentation & Supply

• Monthly capacity: 50 kg
• Lead time: 3-5 business days (stock items)
• Documentation: COA, MSDS, TDS available upon request
• Packaging: 1 g, 5 g, 10 g, 50 g, 100 g in amber glass vials or as requested

Request For Quote

• LyvBio Co., Ltd. — Email: info@lyvbio.com